摘要
目的评价金匮肾气丸联合腹腔镜治疗子宫内膜异位症(endometriosis,EMT)致不孕的肾阳虚患者的促孕效果。方法搜集EMT患者70例,随机分为观察组和对照组,2组均给予常规治疗,观察组加用金匮肾气丸治疗,评价2组治疗前后痛经视觉疼痛评分(VAS)、自然杀伤(NK)细胞、巨噬细胞(MΦ)、CA125水平等指标变化,并比较2组治疗后妊娠情况。结果治疗后,2组VAS及CA125均较治疗前明显下降(P<0.05),且观察组明显低于对照组(P<0.05),2组NK及MΦ均较治疗前明显上升(P<0.05),且观察组明显高于对照组(P<0.05)。治疗后,2组分别有26例和22例在1年内妊娠,分别占74.29%和62.86%,观察组妊娠率显著高于对照组(χ2=9.657,P=0.002);26例和22例妊娠者各有20例和15例足月产,分别占76.92%和68.18%,观察组的足月产率显著高于对照组(χ2=10.083,P=0.001)。结论金匮肾气丸具有免疫调节作用,对EMT致不孕的肾阳虚患者有较好的促孕作用。
Objective To evaluate the effect of kidney-qi-tonifying pills on the endometriosis patients with infertility who underwent laparoscopy.Methods Seventy endometriosis cases with infertility were randomly divided into observation group and control group.Both groups were given common treatment and the observation group was added kidney-qi-tonifying pills orally.Dysmenorrhea visual pain score(VAS),natural killer(NK)cells and macrophages(MF)and CA125 level of two groups were evaluated before and after the treatment.The pregnancy rate after treatment was compared between two groups.Results After treatment,VAS and CA125 in two groups decreased significantly when compared with those before treatment(P〈0.05).After treatment,VAS and CA125 of observation group was significantly lower than that of control group(P〈0.05).NK and MF in the two groups after treatment increased significantly when compared with those before treatment(P〈0.05).NK and MF in observation group were significantly higher than those in control group(P〈0.05).After treatment,there were 26 and 22pregnant cases in observation group and control group with in 1years,accounted for 74.29%and 62.86%,respectively,with significantly higher pregnancy rate in observation group than in control group(χ^2=9.657,P=9.657).Above pregnant 26 and 22patients had 20 and 15cases of full term birth,with 76.92% and 68.18%term labor rate,respectively,and significantly higher term labor rate in observation group than in control group(χ^2=10.083,P=0.001).Conclusion Kidney-qi-tonifying pills can modulate immunity of infertile EMT patients with kidney Yang deficiency and has a certain effect on promoting gestation.
出处
《中西医结合研究》
2015年第3期123-125,共3页
Research of Integrated Traditional Chinese and Western Medicine
关键词
子宫内膜异位症
不孕症
肾阳虚
金匮肾气丸
免疫调节
endometriosis
infertility
kidney Yang deficiency
kidney-qi-tonifying pills
immune regulation