摘要
目的探讨在辅助生殖过程中染色体多态性对胚胎发育结局与妊娠结局的影响。方法回顾分析湖州妇幼保健院生殖医学中心2010年10月至2013年10月行IVF/ICSI-ET共626例患者的染色体核型及临床资料,研究染色体多态性对辅助生殖结局的影响。结果 626例患者中28例(4.47%)染色体核型多态性。进一步分析这些发现染色体多态性患者受精率、正常受精率、优质胚胎率与对照组无显著差异,临床妊娠率与每移植周期活产率与患者也无显著差异,但是流产率显著高于对照组。结论染色体核型多态性组胚胎结局提高ART中患者流产率。
Objective：To analyze the result of fertilization,embryo development and the clinical outcome of oocytes with chromosome polymorphismon after in vitro fertilization（IVF）or intracytoplasmic sperm injection（ICSI）. Methods：A retrospective analysis was performed on the karyotype and clinical data of a total of 626 patients in the Reproductive Center of Huzhou Maternity and Child Health Care Hospital from Oct 2010 to Oct 2013,visit the ART embryo developmentand pregnancy outcome. Results：Twenty-right（4.47%）cases of chromosome polymorphismon were found in the 626 patients. Compared to the control group,the differences of fertilization rate,normal fertilization rate were not statistically significant,the rate of good quality embryos in chromosome polymorphismon group was 53.43%,while that of control group was 56.87%,and with no significant difference（P〉0.05）. The pregnancy rate and live birth rate of the two group were also no significant difference（P〈0.05）,but the miscarriage of the chromosome polymorphismon was 33.3%,that was higher significantly than the control group. Conclusion：The miscarriage rate of chromosome polymorphismon was higher than the control group.
出处
《中国优生与遗传杂志》
2015年第7期106-108,共3页
Chinese Journal of Birth Health & Heredity
基金
生殖遗传教育部重点实验室(浙江大学)/浙江省女性生殖健康重点实验室开放基金资助项目资助。项目编号:2012-RG/RH-0003
关键词
染色体多态性
IVF/ICSI-ET
胚胎结局
临床结局
Chromosome polymorphismon
IVF/ICSI-ET
Fertilization
Development of embryo
Clinical pregnancy
