摘要
目的：探讨氢波谱（~1H-MRS）分析对中度创伤性颅脑损伤（TCI）的损伤程度及预后的临床意义。方法：将30例中度TCI患者和10例志愿者做氢波谱检查,观察损伤组与对照组、损伤组患侧与对侧的N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）、乳酸（Lac）及NAA/Cho,NAA/Cr,Cho/Cr值的变化。结果：NAA/Cho,NAA/Cr值损伤组较对照组以及损伤组患侧脑白质较对侧同一部位正常脑白质（NAWM）降低明显,而Cho/Cr值升高明显。NAA/Cho,NAA/Cr,Cho/Cr值变化与TCI患者GCS,GOS具有相关性。结论：氢波谱分析对中度创伤性颅脑损伤的早期诊治具有重要指导价值。
Objective：To investigate the clinical significance of proton magnetic resonance spectroscopy OH-MRS） on extent and prognosis of moderate traumatic craniocerebral injury（TCI）.Methods：30 moderate TCI patients and 10 volunteers were accepted proton magnetic resonance spectroscopy.The change of N-acetyl aspartate（NAA）,choline（Cho）,creatineCCr）,lactate（Lac）,NAA/Cho,NAA/Cr and Cho/Cr of ipsilateral and contralateral white matter of brain were observed.Results：The value of NAA/Cho and NAA/Cr in white matter of patients was decreased significantly than that of control group,however the value of Cho/Cr was significantly increased.The value changes of NAA/Cho,NAA/Cr,Cho/Cr in white matter of patients was correlated with GCS and GOS.Conclusion;Proton magnetic resonance spectroscopy has an important guiding significance for the early diagnosis and treatment of moderate traumatic craniocerebral injury.
出处
《华夏医学》
CAS
2015年第3期16-19,共4页
Acta Medicinae Sinica
基金
惠州市科技计划重点课题资助项目(20140805)
关键词
创伤型颅脑损伤
氢质子磁共振波谱
N-乙酰天门冬氨酸
胆碱
肌酸
traumatic craniocerebral injury
proton magnetic resonance spectroscopy
N-acetyl aspartate
choline compound
creatine compound
