摘要
目的:观察炎琥宁联合干扰素治疗小儿手足口病的效果及对心肌酶和肝功能的影响。方法:96例小儿手足口病患儿随机分为观察组和对照组各48例。观察组予炎琥宁联合干扰素治疗,对照组单用干扰素治疗。疗程均为5 d。疗程结束后评价两组患儿疗效,比较两组临床症状消失时间、住院时间,心肌酶与肝功能水平变化及治疗过程中药品不良反应发生情况。结果:观察组治疗5 d后总有效率(93.75%)显著高于对照组(77.08%,P<0.05)。两组治疗后ALT水平和磷酸肌酸激酶、乳酸脱氢酶、磷酸肌酸激酶同工酶等心肌酶水平均较治疗前显著下降(P<0.05),且观察组ALT与心肌酶水平均显著低于对照组(P<0.05)。观察组患儿退热时间、口腔溃疡消退时间、手足皮疹消退时间及住院时间均显著短于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:炎琥宁联合干扰素治疗小儿手足口病效果显著,可明显缩短临床症状消退时间及住院时间,改善肝功能与心肌酶水平,不良反应少,值的临床推广应用。
Objective：To observe the effect of Yanhuning injection combined with interferon in treatment of children with hand, foot and mouth disease（ HFMD）, and its influence on myocardial enzymes and liver function. Methods ：96 cases of children with HFMD were randomly divided into observation group and control group , each 48 cases. Observation group was given Yanhuning injection combined with interferon, while control group was treated by interferon. The cource of two groups were all 5 days. The effects of two groups were evaluated, and clinical symptoms disappeared time, hospitalization time, levels of myocardial enzymes and liver function, adverse drug reactions of the two groups were compared. Results：After 5 days treatment, the total efficiency of observation group （93.75%） was significantly higher than controll group （77.08% ,P 〈 0.05 ）. The ALT level and creatine kinase, lactate dehydrogenase, creatine kinase isoenzyme level of two groups were all significantly deeresed than before （ P 〈 0.05 ）, and ALT and those myocardial enzymes levels of observation group were significantly lower than control group（ P 〈 0.05 ）. The fever clearance time, mouth ulcers subside time , hand- foot skin rash subsided time and hospitalization time of observation group were significantly shorter than control group（P 〈 0.05 ）. There was no statistically difference between the two groups in the Incidence of adverse reactions（ P 〉 0.05 ）. Conclusion ： Yanhuning injection combied with interferon in treatment of children with HFMD, it is effective, it can significantly reduced the clinical symptoms subside time, shorter hospitalization time, improved liver function and myocardial enzyme levels, and the adverse reactions is very less. It had important clinical significance.
出处
《药物流行病学杂志》
CAS
2015年第7期400-403,共4页
Chinese Journal of Pharmacoepidemiology
关键词
炎琥宁
干扰素川
儿手足口病
心肌酶
肝功能
Yanhuning injection
Interferon
Pediatric hand,foot and mouth disease
Myocardial enzymes
Liver function
