摘要
目的 分析研究血清人附睾分泌蛋白4（HE4）、糖类抗原125（CA125）和恶性肿瘤特异性生长因子（TSGF）联合检测在卵巢肿瘤中的诊断价值。方法 选择2014年1月~2014年6月妇产科治疗的卵巢恶性肿瘤患者73例,卵巢良性肿瘤患者73例,同时选取70例健康体检女性。采用酶联免疫分析（ELISA）法测定血清HE4水平,采用电化学发光法（ECLIA）检测血清CA125水平,采用比浊法检测TSGF水平。结果 血清HE4、CA125和TSGF的表达水平在卵巢恶性肿瘤组明显高于其他两组,组间比较差异有统计学意义（P〈0.05）;良性肿瘤组和健康组血清HE4、CA125和TSGF水平比较差异有统计学意义（P〈0.05）;血清HE4、CA125和TSGF各单项及联合检测诊断卵巢肿瘤的阳性率与健康对照组比较差异有统计学意义（P〈0.05）;三项指标联合检测卵巢肿瘤的阳性率显著高于各指标的单项检测（P〈0.05）。结论 血清HE4、CA125和TSGF联合检测有较高的灵敏度,可以明显提高卵巢肿瘤诊断的准确性,在卵巢肿瘤的诊断中具有重要的临床意义。
Objective To study the significance of serum human epididymis protein 4 （HE4）, carbohydrate antigen 125 （CA125） and tumor specific growth factor （TSGF） in the diagnosis of ovarian tumor. Methods A total of 73 pa- tients with malignant ovarian tumor, 73 patients with benign ovarian tumor and 70 healthy examinees were recruited from the Department of Gynaecology and Obstetrics, General Hospital of Fushun Mining Bureau between January 2014 to June 2014. Serum HFA levels were detected with enzyme linked immunosorbent assay （ELISA）, serum CA125 levels were as- sayed with electrochemical luminescence immunoassay （ ECLIA）, and TSGF levels were determined with turbidimetry method. Results The expression levels of serum HFA, CA125 and TSGF in malignant ovarian tumor patients were sig- nificantly higher than that in the other two groups （P 〈 0. 05 ）. The difference of serum HE4, CA125 and TSGF levels was significant between benign ovarian tumor group and healthy group （P 〈 0. 05）. The single or combined detection of serum HFA, CA125 and TSGF levels for the diagnosis of ovarian tumor showed significant differences compared with the healthy group （P 〈 0. 05 ） ; further, the combined detection of these indicators is significantly better than the detection of each indicator alone （P 〈 0. 05）. Conclusions The combined detection of serum HFA, CA125 and TSGF has a high sensitivity and obviously improves the diagnostic accuracy of ovarian tumors, therefore it is of great significance in the di- agnosis of ovarian tumors.
出处
《航空航天医学杂志》
2015年第7期798-799,共2页
Journal of Aerospace medicine
