摘要
目的探讨肾康注射液对血液透析患者残余肾功能的保护作用。方法以2010年6月～2013年5月本院收治的93例血液透析患者为研究对象，依据随机数表法分为肾康注射液治疗组（治疗组）和常规治疗组（对照组），分别于治疗前后测定患者的24h尿量、血肌酐（Scr）、尿素氮（BUN）、内生肌酐清除率（Ccr）、残余肾功能（RRF）、白蛋白（ALB）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子（TNF-α）水平。结果两组患者的24h尿量、RRF及对照组患者的Ccr较同组治疗前明显降低，Scr、BUN明显升高，且组间差异明显。以上差异均具有统计学意义（P〈0．05）。两组患者的CRP、TNF—a较同组治疗前明显升高，IL-6明显降低，且组间差异明显，以上差异均具有统计学意义（P〈0．05）。两组患者的ALB较同组治疗前明显升高，但组间差异不具有统计学意义（P〉0．05）。结论肾康注射液可保护血液透析患者的残余肾功能，其作用机制可能与抑制机体炎性反应有关。
Objectives To investigate the protective effect of Shenkang Injection in hemodialysis patients residual renal function. Methods To analyse 93 patients of hemodialysis treated in our hospital from June 2010 to May 2013. Based on a random number table method, All were divided into Shenyang injection group（treatment group） and the conventional treatment group （control group）. 24h urine of patients were measured before and after treatment as well as serum cretonne（Scr） ,blood urea nitrogen （BUN）, cretonne clearance rate （Ccr）, residual renal function （ RRF ）, albumin （ ALB ）, C - reactive protein （ CRP ）, interleukin - 6 （ IL - 6 ）, tumor necrosis factor （ TNF - α） levels. Results The two groups of patients 24h urine, RRF Ccr of patients and the control group compared with the former group therapy significantly reduced, Scr, BUN significantly increased, and between - group differences apparent. Both differences were statistically significant （ P 〈 0.05 ）. Two groups of patients CRP, TNF - α treatment compared with the former group was significantly increased, IL - 6 was significantly reduced, and the group significant difference between the above differences were statistically significant （ P 〈 0.05 ）. ALB two groups were compared with pro - treatment group was significantly increased, but the difference between the groups was not statistically significant（ P 〉0.05 ）. Conclusions Shenkang injection can protect residual renal function in hemodialysis pa- tients ; its mechanism of action may inhibit the body＇sinflammatory response.
出处
《国际泌尿系统杂志》
2015年第4期547-549,共3页
International Journal of Urology and Nephrology
关键词
肾透析
注射剂
Renal Dialysis
Injectio
