摘要
目的分析高血压早期强化降压治疗对脑出血(ICH)的影响。方法选取医院2012年6月至2014年7月收治的高血压脑出血患者58例,按照计算机数字法分为对照组和试验组,各29例。对照组患者接受常规降压治疗,试验组患者接受早期强化降压治疗。采用头颅CT检测、美国国立卫生研究院卒中量表(NIHSS)评分及改良Rankin量表(mRS)评分对患者治疗前后的血肿量、水肿量及血肿扩大例数进行比较,比较两组临床疗效和Barthel指数(BI)。结果治疗14 d后,试验组NIHSS评分明显低于对照组(P<0.05);治疗后24 h,试验组血肿量为(11.98±6.80)m L、血肿扩大例数比例为6.90%,明显少于对照组的(14.75±7.74)m L和37.93%(P<0.05);治疗3个月后,试验组mRS评分鉴定为中重度残疾的占27.59%,明显低于对照组的58.62%(P<0.05);试验组的总有效率为96.55%,明显高于对照组的65.52%(P<0.05);试验组BI评分显著低于对照组(P<0.05);治疗前两组格拉斯哥昏迷量表(GCS)评分无统计学差异(P>0.05),但试验组治疗1周后GCS评分明显高于对照组(P<0.05)。结论高血压早期强化降压治疗可显著减少脑出血患者血肿扩大、减轻脑水肿发生率,恢复和改善神经功能,值得临床推广。
Objective To analyze the influence of early intensive antihyertensive treatment on intracerebral hemorrhage（ ICH） in patients with hypertension. Methods 58 patients with hypertensive ICH in the hospital from June 2012 to July 2014 were selected and divided into the control group and the experimental group according to the computer digital method,29 cases in each group. The control group adopted the routine treatment,while the experimental group was given early intensive antihypertensive treatment. The skull CT detection,United States National Institutes of Health Stroke Scale（ NIHSS） scores and modified Rankin scale（ mRS） scores were adopted to compare the hematoma volume,edema volume and cases of hematoma expansion before and after treatment between the two groups,at the same time the clinical curative effect and Barthel index（ BI） were compared between the two groups. Results The NIHSS score at14 d after treatment in the experimental group was obviously lower than that in the control group（ P〈0. 05）; the hematoma volume and proportion of expansion cases of hematoma at 24 h after treatment in the experimental group was（ 11. 98 ± 6. 80） m L 6. 90%,which was significantly less than（ 14. 75 ± 7. 74） m L and 37. 93% in the control group（ P〈0. 05）; the mRS score identified as moderate and severe disability after 3- month treatment in the experimental group accounted for 27. 59%,which was significantly lower than 58. 62%in the control group（ P〈0. 05）; the total effective rate in the experimental group was 96. 55%,which was significantly higher than65. 52% in the control group（ P〈0. 05）; the BI score in the experimental group was significantly lower than that in the control group（ P〈0. 05）; the GCS score before treatment had no statistical difference between the two groups（ P〉0. 05）,but which at 1 week after treatment in the experimental group was significantly higher than that in the control group with statistically significant difference（ P〈0. 05）. Conclusion Early intensive antihypertensive treatment can significantly reduce the hematoma expansion,reduce the incidence rate of cerebral edema,restore and improve the nerve function,and deserves to be clinically promoted.
出处
《中国药业》
CAS
2015年第14期48-50,共3页
China Pharmaceuticals
关键词
高血压
脑出血
早期强化降压
hypertension
intra cerebral hemorrhage
early intensive antihy perintension
