摘要
目的探讨高水碘对儿童碘营养现状及甲状腺功能的影响。方法2014年，在天津市选择水源性高碘病区（静海县）和适碘地区（滨海新区大港）各1个乡，每个乡选择8～12岁儿童100名为调查对象，测定儿童身高、体重、饮用水碘、尿碘、甲状腺激素[游离三碘甲状腺原氨酸（n13）、游离甲状腺素（n）、促甲状腺激素（TSH）]和甲状腺抗体[过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）]，并对儿童进行甲状腺B超检查。结果水源性高碘病区和适碘地区分别检测了10、10份水样，水碘分别为（304．39±3．33）、（141．58±6．00）μg／L；共检测了99、96份8～12岁儿童尿样，尿碘分别为（514．03±286．68）、（196，17±gg．56）μg／L；对200名8-12岁儿童进行甲状腺B超检查，甲状腺肿大率分别为9．0％（9／100）、1．0％（1／100）。甲状腺形态异常率分别为27．0％（27／100）、2．0％（2／100）；分别检测血清74、96份，TSH、TPOAb的异常率分别为8．11％（6／74）、1．04％（1／96），（36．49％（27／74）、14．58％（14／96）。结论水源性高碘病区存在碘营养过剩情况，该地区儿童甲状腺形态学变化和甲状腺功能异常均高于适碘地区，建议在水碘含量超过300斗g／L的地区采取改水降碘措施。
Objective To investigate iodine nutritional status and thyroid function of school-age children in high water iodine areas and explore the influence of excess iodine intake on their health. Methods Two hundred children aged 8 to 12 were selected in one high water iodine and one suitable iodine areas in 2014. Height and weight, iodine level in drinking water, urinary iodine and FT3, FT4, TSH, TPOAb and TGAb were measured. In addition,goiter and thyroid diseases were examined by B ultrasound. Results In high water iodine and suitable iodine areas, 10 water samples were examined, and water iodine was （304.39 ± 3.33） and （141.58 ± 6.00） μg/L, respectively. Ninety-nine and 96 urine samples of children from the above mentioned areas were examined, and urinary iodine was （514.03 ± 286.68） and （196.17 ± 88.56） μg/L. One hundred children aged 8 to 12 years old were examined by B ultrasound, and their goiter rates were 9.0% （9/100） and 1.0% （1/100）; thyroid morphology abnormal rates were 27.0% （27/100） and 2.0% （2/100）. Seventy-four and 96 serum samples were tested, and TSH, TPOAb abnormal rates were 8.11% （6/74）, 1.04% （1/96）, （36.49% （27/74） and 14.58% （14/96）. Conclusions School-age children＇s iodine nutrition is excessive in high water iodine areas. Morphological changes of the thyroid and thyroid dysfunction are higher than those of iodine suitable areas. We suggest to change the water source to reduce iodine content in the areas where iodine level exceeds 300 μg/L.
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2015年第7期518-521,共4页
Chinese Journal of Endemiology
基金
国家自然科学基金（81372934）
天津市卫生局科技基金（2013KY18／2013KY19）
关键词
高碘
碘营养
甲状腺激素
甲状腺肿
Iodine excess
Iodine nutrition
Thyroid hormone
Goitre
