摘要
目的评价尿毒清颗粒联合还原型谷胱甘肽治疗慢性肾功能不全的临床疗效及安全性。方法将73例慢性肾功能不全患者随机分为对照组35例和试验组38例。对照组限制蛋白质饮食、纠正感染及电解质紊乱级酸碱平衡,解除尿路梗阻及禁用肾毒性药物,同时给予还原型谷胱甘肽1.8 g+0.9%氯化钠100m L静脉滴注,每日2次,疗程为4周。试验组在对照组的基础上,同时口服尿毒清颗粒每次5 g,每日4次,2组疗程均为4周。比较2组治疗前后的临床疗效、肾功能指标改善程度以及不良发应发生率有无差别。结果治疗4周后,试验组总有效率76.32%显著高于对照组51.43%(P<0.05)。治疗后,2组患者肾功能指标较治疗前均有明显好转(P<0.05),且试验组肌酸酐、尿素氮、尿酸等指标低于对照组(P<0.05),而肌酸酐清除率高于对照组(P<0.05)。试验组治疗期间发生皮疹1例,恶心呕吐1例,不良反应发生率为5.26%,对照组发生恶心呕吐2例,不良反应发生率为5.71%,2组比较差异无统计学意义(P>0.05)。结论尿毒清颗粒联合还原型谷胱甘肽治疗慢性肾功能不全的临床疗效确切,可显著改善患者肾功能,且不增加不良反应发生率。
Objective To investigate the clinical efficacy and drug related toxicities of Niaoduqing combined with reduced glutathione in the treatment of chronic renal insufficiency. Methods Seventy-three cases with chronic renal insufficiency were recruited in our study. The recruited73 cases were randomly divided into experiment group（ n = 38） and control group（ n = 35）. All the patients were treated with basic treatment such anti infection,forbidden use of renal toxicity drugs and improve the electrolyte disorder. And patients in the control group were administered reduced glutathione 1. 8 g ＋ 0. 9% Na Cl 100 m L twice per day for 4weeks in the control group. Patients in the treatment group administered the same schedule reduced glutathione as well as niaoduqing 5 g orally 4times per day for 4 weeks. After treatment the clinical efficacy,renal function and drug related toxicity were evaluated between the two groups.Results The total efficacy were 76. 32% and 51. 43% in the control and experiment group respectively with experiment group much higher than the control group（ P〈0. 05）. The renal function were all improved in both the experiment and control group（ P〈0. 05）. And the serumcreatinine,blood urea nitrogen,uric acid were significant lower,the creatinine clearance rate was significant higher in the experiment group compared to control group after treatment（ P〈0. 05）. The drug related adverse event rate were5. 26% and 5. 71% in the experiment and control group respectively with no statistical difference（ P〈0. 05）. Conclusion Niaoduqing combined with reduced glutathione is effective and safety in the treatment of chronic renal failure which could significant improve the renal function.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第14期1384-1386,共3页
The Chinese Journal of Clinical Pharmacology
