摘要
目的 观察中西医结合治疗奥沙利铂周围神经病变的临床效果,探讨临床应用价值。方法 选择2010年1月~2014年12月浙江省台州市第一人民医院诊治的90例奥沙利铂致周围神经病变的患者作为研究对象,按照随机双盲原则将其分为中西医结合组与单纯西医组,各45例。单纯西医组应用甲钴胺1.0 mg＋0.9%氯化钠注射液100 m L静脉滴注,1次/d。中西医结合组在单纯西医组的基础上加用中药治疗,将中药浸泡于2500 m L的水中,煎煮30 min,利用熏蒸桶使蒸汽作用于患处,熏蒸后用浸泡过药物的浴巾淋洗患处,30 min/次,1次/d,7 d为1个疗程。比较两组运动传导速度、感觉传导速度及治疗效果差异。结果 中西医结合组临床症状改善时间[（2.98±1.05）d]短于单纯西医组[（4.98±1.11）d]（P〈0.05）;两组治疗前运动传导速度、感觉传导速度比较差异无统计学意义（P〉0.05）,治疗1个疗程后,两组患者均有所提高（P〈0.05）,但中西医结合组运动传导速度[（46.56±5.03）m/s]、感觉传导速度[（52.12±5.09）m/s]高于单纯西医组[（41.25±4.76）、（47.31±6.23）m/s],治疗总有效率（95.56%）也高于单纯西医组（82.22%）,差异均有统计学意义（P〈0.05）。结论 中西医结合治疗奥沙利铂周围神经病变能够迅速改善临床症状,提高运动传导及感觉传导速度,提高治疗效果。中药熏洗治疗操作简单,患者易接受、适应性强、经济实惠,是一种较为理想可靠的治疗方式。
Objective To observe the clinical effect of integrated Chinese and Western medicine in the treatment of pe- ripheral neuropathy caused by Oxaliplatin, so as to investigate the value of clinical application. Methods 90 cases of patients with peripheral neuropathy caused by Oxaliplatin diagnosed and treated in the First People＇s Hospital of Taizhou City from January 2010 to December 2014 were chosen as research objects, according to the randomized dou- ble blind principle, the patients were divided into integrated Chinese and Western medicine group and single western medicine group, with 45 cases in each group, single western medicine group was given Mecobalamin 1.0 rag±0.9% Sodium Chloride Injection 100 mL intravenous drip, once a day. On basis of single western medicine group, the inte- grated Chinese and Western medicine group was added with traditional Chinese medicine, Chinese medicine was soaked in 2500 mL water, boiling for 30 min, fumigation barrel was used to make the steam acting on the affected part, after fumigation, the bath towel soaked with the drug was used to drip wash affected part, once 30 min, once a day, 7 days were as a course. The differences of motor conduction velocity, sensory conduction velocity and therapeutic ef- fect between the two groups were compared. Results The improvement time of clinical symptoms of integrated Chinese and Western medicine group [（2.98±1.05） d] was shorter than that of single western medicine group [（4.98±1.11） d] （P 〈 0.05）; there were no statistically significant differences of motor conduction velocity, sensory conduction velocity before treatment between the two groups （P 〉 0.05）, after a course of treatment, both groups were improved, but the motor con- duction velocity [（46.56±5.03） m/s] and ensory conduction velocity [（52.12±5.09） m/s] in the integrated Chinese and Western medicine group were significantly faster than those of single western medicine group [（41.25±4.76）, （47.31± 6.23） m/s], the total effective rate （95.56%） was also higher than that of single western medicine group （82.22%）, the differences were all statistically significant （P 〈 0.05）. Conclusion Integrated Chinese and Western medicine in the treatment of peripheral neuroDathy caused by Oxaliplatin can improve the clinical svmntoms rapidly, raise the motor conduction velocity, sensory conduction velocity, enhance the therapeutic effect. The operation of traditional Chinese medicine fumigation is simple, which is easy to be accepted by patients, with strong adaptability, economic benefits, so it is an ideal and reliable therapy method.
出处
《中国医药导报》
CAS
2015年第21期131-134,共4页
China Medical Herald
基金
浙江省台州市黄岩区科技计划项目(2014054-1)
关键词
中西医结合
奥沙利铂
周围神经病变
临床效果
Integrated Chinese and Western medicine
Oxaliplatin
Peripheral neuropathy
Clinical effect
