摘要
目的 分析影响同步放化疗中晚期食管癌患者的预后因素.方法 对2008年1月至2011年12月收治的同步放化疗中晚期食管癌患者200例的临床资料进行回顾性分析.采用调强放疗治疗92例,常规放疗治疗108例;两组均采用紫杉醇加不同铂类（顺铂、奈达铂、奥沙利铂、洛铂）化疗,化疗2～4个周期.结果 调强放疗、常规放疗组的3年总生存率分别为63.6％和38.9％（x2=12.102,P=0.001）;顺铂、奈达铂、奥沙利铂和洛铂化疗的3年生存率分别为44.6％、57.5％、52.5％和52.5％,差异无统计学意义（x 2=2.756,P=0.431）;化疗2、3和4个周期患者3年生存率分别为44.1％、51.6％和57.4％,差异无统计学意义（x2=2.497,P=0.287）.单因素分析显示,与预后相关的是X线病变长度、M分期、第6版UICC分期和放疗方法,多因素分析显示患者性别、X线片病变长度和放疗方法是独立的预后因素.结论 影响同步放化疗中晚期食管癌患者的独立预后因素主要是X线病变长度和放疗方法.
Objective To retrospectively analyze the prognostic factors of advanced esophageal carcinoma （EPC） with concurrent chemoradiotherapy.Methods A total of 200 advanced EPC patients between January 2008 and December 2011 were reviewed,and all of them received concurrent chemoradiotherapy,either IMRT or CRT.Among them,there were 92 and 108 patients in the IMRT and CRT group,respectively.The chemotherapy scheme was paclitaxel combined with different platinum drugs （cisplatin,nedaplatin,oxaliplatin or lobaplatin）.The number of chemotherapy cycles was 2-4.Results Patients who received IMRT had a significant higher 3-year overall survival （OS） than that who received CRT （63.6 % vs 38.9 %,x2 =12.102,P =0.001）.Three-year OS differed no significantly between different chemotherapy regimens.There were 44.6 %,57.5 %,52.5 % and 52.5 % for those who received cisplatin,nedaplatin,oxaliplatin and lobaplatin,respectively （x2 =2.756,P =0.431）.Patients received different cycles of chemotherapy had comparable treatment outcome,and the overall survival were 44.1%,51.6 % and 57.4 % for those who underwent 2,3 and 4 chemotherapy cycles at 3 years,without any statistical significance （x2 =2.497,P =0.287）.Univariate analysis indicated that lesion length on X-ray,M stage,6th edition UICC staging and radiotherapy methods were the potential predictive factors.Multivariate analysis shown that gender,lesion length on X-ray and radiotherapy methods were the significant prognostic factors.Conclusion The significant prognostic factors for advanced EPC with concurrent chemoradiotherapy are mainly lesion length on X-ray and radiotherapy methods.
出处
《肿瘤研究与临床》
CAS
2015年第6期385-388,393,共5页
Cancer Research and Clinic
基金
福建省科技厅重点项目（2011Y0014）
关键词
食管肿瘤
同步放化疗
放射疗法
药物疗法
联合
预后因素
Esophageal neoplasms
Concurrent chemoradiotherapy
Radiotherapy
Drug therapy,combination
Prognostic factors
