摘要
目的探讨老年糖耐量减低患者发生冠心病的高危因素。方法收集糖耐量减低患者60例(A组),另选取健康人群60例归类为糖耐量正常组(B组)60例。比较2组BMI、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、血清C-反应蛋白(CRP)、胰岛素抵抗指数(HOMA-IR)水平,以及冠状动脉钙化积分(CACS)>400、踝臂指数(ABI)<0.9的分布。结果 A组BMI、2hPG、CRP、HOMA-IR、TC、TG、LDL-C均明显高于B组(P<0.05),HbA1c明显低于B组(P<0.05);A、B组CACS>400分别占35.0%(21/60)、6.7%(4/60),A、B组ABI<0.9分别占40.0%((24/60)、8.3%((5/60),2组比较差异均有统计学意义(均P<0.05)。结论肥胖、高血脂、胰岛素抵抗是糖耐量减低患者发生冠心病的高危因素,加强对具有高危因素的糖耐量异常患者的干预对于冠心病的防治具有重要意义。
Objective To investigate the high risk factors for coronary heart disease in elderly patients with impaired glucose tolerance.Methods Body mass index(BMI),fasting blood glucose (FPG),2-hour postprandial blood glucose(2-hPG),glycosylated hemoglobin(HbA1c),serum to-tal cholesterol(TC),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),serum C-reactive protein(CRP),insulin resistance index(HO-MA-IR)and distribution of coronary artery calcification score(CACS)>400 and ankle brachial index(ABI)were compared between 60 patients with impaired glucose tolerance(group A)and 60 healthy subjects with normal glucose tolerance(group B).Results Compared with group B,the BMI,2 hPG,CRP,HOMA-IR,TC,TG and LDL-C significantly increased and HbA1c significantly decreased in group A(P <0.05).The prevalence of CACS>400 was 35.0%(21/60)in group A, and 6.7%(4/60)in group B.The prevalence of ABI<0.9 was 40.0%(24/60)in group A,and 8.3%(5/60)in group B.The differences were significant between the two groups(P < 0.05). Conclusion The obesity,hyperlipidemia and insulin resistance are the high risk factors for coro-nary heart disease in patients with impaired glucose tolerance.The strengthening of intervention for abnormal glucose tolerance is of great significance for the prevention and treatment of coro-nary heart disease.
出处
《实用临床医学（江西）》
CAS
2015年第7期24-26,共3页
Practical Clinical Medicine
关键词
糖耐量减低
冠心病
高危因素
老年人
impaired glucose tolerance
coronary heart disease
risk factors
elderly
