摘要
目的研究总结托吡酯治疗癫痫患者的临床疗效及不良反应,为临床提供可参考依据。方法纳入我院2010年1月~2013年7月癫痫患者52例,所有患者采用托吡酯进行治疗,随访3个月、半年、一年和两年的临床效果,并对其不良反应现象进行总结。结果经过随访发现,3个月时有2例患者因为不耐受退出实验。剩余50例患者3个月总有效率为54.0%,半年总有效率为70.0%,一年总有效率为74.0%,两年总有效率为80.0%,总有效率呈逐渐增长趋势,两年总有效率跟治疗3个月总有效率对比差异显著,〈0.05;不良反应情况除了2例不耐受（主要是出现异常兴奋和反应迟钝）,还有23例出现其他症状,不良反应发生率为48.08%。结论托吡酯治疗癫痫患者的临床疗效随着用药时间的延长而提高,对于出现不耐受或严重不良反应的患者应停止用该药物治疗。
Objective Research summary clinical efficacy and adverse reactions of topiramate in treatment of epilepsy patients, provides the reference for clinical. Methods 52 cases included in our hospital in 2010 January ~ 2013 July epilepsy patients. All patients received topiramate treatment, follow-up of 3 months, half a year, one year and two years clinical effect and the adverse reaction phenomenon were summarized in this paper. Results 2 patients were followed up for 3 months. The remaining 50 patients 3 months the total efficiency was 54.0%, the first half of the total effective rate was 70.0%, one year the total efficiency was 74.0%, two years the total effective rate was 80.0%, the total efficiency was gradually increasing trend, two years the total efficiency is related to the treatment of 3 months the total efficiency had significant differences, P〈0.05. Adverse reactions except for the 2 cases of intolerance（mainly is excited and unresponsive）, and 23 cases had other symptoms, adverse reactions occurred rate was 48.08%. Conclusion The clinical efficacy of topiramate in treatment of epilepsy patients with the extension of treatment time and improve, for intolerance or serious adverse reactions of the patients should stop treatment with the drug.
出处
《中国卫生标准管理》
2015年第18期110-111,共2页
China Health Standard Management
关键词
托吡酯
癫痫
疗效
不良反应
Topiramate
Epilepsy
Efficacy
Adverse reaction
