摘要
目的调查延边地区朝鲜族和汉族学生肥胖和胰岛素抵抗(IR)及其相关脂肪细胞因子,分析肥胖和IR与不同脂肪细胞因子的关联程度。方法在吉林省延边朝鲜族自治州选择4所小学校,采用整群抽样的方法,抽取3879例小学生(朝鲜族2011例和汉族1868例)作为研究对象,通过问卷调查和体格检查的方式,调查研究对象的一般情况,测定体质指数(BMI)、腰围(WC)和空腹血糖(FBG)、胰岛素、脂联素、瘦素及肿瘤坏死因子-α(TNF-α)水平。采用稳态模式评估法(HOMA)估测人体IR(HOMA-IR)。结果 (1)朝鲜族学生的脂联素水平显著低于汉族学生,朝鲜族学生的瘦素、HOMA-IR、WC和BMI的水平显著高于汉族学生,不同民族学生上述指标平均水平比较差异均有统计学意义(P<0.01)。(2)BMI、WC和HOMA-IR与脂联素呈负相关(r=-0.178、-0.172和-0.137),其与瘦素(r=0.572、0.535和0.265)和TNF-α(r=0.110、0.119和0.691)呈正相关,其相关性均有统计学意义(P<0.001),而且朝鲜族和汉族学生肥胖和HOMA-IR与不同脂肪细胞因子的相关性程度有所不同。(3)多元线性回归分析结果显示,BMI、WC和HOMA-IR与不同脂肪细胞因子间均有显著的线性依存关系,且与脂联素(Beta=-0.022、-0.019和-0.042)、瘦素(Beta=0.154、0.069和0.039)和TNF-α(Beta=-0.082、0.018和0.654)的关联程度有所不同。结论延边地区小学生不同肥胖指标、HOMA-IR和脂肪细胞因子的分布特征出现明显的民族差异;BMI、WC和HOMA-IR与不同脂肪细胞因子的关联程度有所不同,BMI和WC与瘦素的关联程度大于HOMA-IR,HOMA-IR与脂联素和TNF-α的关联程度大于BMI和WC。
Objective To investigate the different types of obesity,insulin resistance（ IR） and its related adipocytokines,and to analyze the association of adipocytokines with obesity and insulin resistance in Korean-Chinese and Han nationality pupils of Yanbian area. Methods A total of 3879 elementary school students（ 2011 of Korean-Chinese and1868 of Han nationality） aged 8- 12 years old were selected. Using epidemiological investigation. Combined with laboratory measurement,the body mess index（ BMI）,waist circumference（ WC） and fasting blood glucose（ FBG）,insulin,adiponectin,leptin and tumor necrosis factor-alpha（ TNF-α） levels were measured. The homeostasis model assessment（ HOMA） method was used to estimate the human IR（ HOMA-IR）. Results（ 1） The levels of adiponctin and TNF-α in Korean-Chinese pupils was lower than that in Han nationality pupils（ P〈0. 01）,and the levels of leptin,HOMA-IR,WC and BMI in Korean-Chinese pupils were higher than that in Han nationality pupils（ P〈0. 01）.（ 2） BMI,WC and HOMA-IR was negatively related with adiponectin（ r =- 0. 178,- 0. 172 and- 0. 137,P〈0. 001）,and that were positively related with leptin（ r =0. 572,0. 535 and 0. 265,P〈0. 001） and TNF-α（ r = 0. 110,0. 119 and 0. 691,P〈0. 001）. There were nationality differences in the correlation of BMI,WC and HOMA-IR in the different adipocytokines.（ 3） The multivariate regression analysis showed that there was a significant linear regression between BMI,WC and HOMA-IR and adiponectin（ Beta =- 0. 022,- 0. 019 and- 0. 042）,leptin（ Beta = 0. 154,0. 069 and 0. 039）and TNF-α（ Beta =- 0. 082,0. 018 and 0. 654）,there were different association of BMI, WC and HOMA-IR in the different adipocytokines. Conclusion There is significant difference for the distribution of obesity, HOMA-IR and its related adipocytokines between two nationality pupils of Yanbian area. BMI,WC and HOMA-IR have different association in the different adipocytokines,and the association of BMI and WC in leptin is stronger than that of HOMA-IR,and that of HOMA-IR in TNF-α and adiponectin is stronger than that of BMI and WC.
出处
《卫生研究》
CAS
CSCD
北大核心
2015年第4期581-585,共5页
Journal of Hygiene Research
基金
国家自然科学基金(No.81160349
81260138)
吉林省教育厅基金[No.2012(4)
2013(25)]
关键词
肥胖
胰岛素抵抗
脂肪细胞因子
关联
民族
obesity
insulin resistance
adipocytokines
association
nationality
