摘要
目的探讨局部晚期乳腺癌根治术的疗效及患者术后生活质量和负性情绪。方法选择2011年9月至2015年2月间收治的局部晚期乳腺癌手术患者80例,其中Ⅲ期70例,Ⅳ期10例。部分患者行术前新辅助化疗,同时在无瘤区植入扩张器,行新辅助化疗时同时扩张周围正常皮肤,在化疗缩小病灶后,对其中40例(20例周围皮瓣转移,20例植入扩张器扩张周围皮肤)患者在根治术中提供足够的皮肤软组织供胸壁缺损修复,观察40例患者在接受胸壁大面积皮肤缺损修复方法治疗后的临床效果。结果局部晚期乳腺癌患者治疗后躯体功能、心理功能得分及生活质量总分均高于治疗前,差异均有统计学意义(均P<0.05)。焦虑自评量表(SAS)评分治疗后明显低于治疗前,差异有统计学意义(P<0.05)。对乳腺癌患者的随访结果显示,术后3年内80例乳腺癌患者中有6例出现局部区域复发,10例出现转移,主要转移部位为内乳淋巴结转移、锁骨上淋巴结转移,患者3年后生存68例。结论胸壁大面积皮肤缺损修复方法对局部晚期乳腺癌患者的治疗效果明显,可提高局部晚期乳腺癌患者的生活质量,有效地缓解患者术后焦虑与抑郁情绪,且术后患者转移复发率较低,生存率高。
Objective To explore the locally advanced breast cancer radical surgery for the patient＇s survival quality, negative emotions and postoperative effect. Methods The 80 patients with breast cancer surgery were chosen between September 2011 and February 2011 in Lianjiang People＇s Hospital Among them, 70 patients with stage ]]I, and 10 patients with stage IV. 80 cases of breast cancer were re- ceived neoadjuvant chemotherapy, at the same time implanted expander in tumor free area. When the tumor was smaller, to provide enough skin and soft tissue for repair of the defect of chest wall in the 20 cases with radical surgery. Clinical effect of the 20 patients was observed. Results After treatment of locally ad- vanced breast cancer, patients＇ body function, psychological function score and quality of life scores were higher than before treatment, the difference was statistically significant （ P 〈 0.05 ）. Self-rating anxiety scale （SAS） score after treatment significantly lower than before, the difference is statistically significant （ P 〈 O. 05 ）. The follow-uped results showed that, among 80 patients, in 3 years, 6 cases with local region- al recurrence, 10 cases with metastases. The main metastases was internal mammary lymph node metastasis and supraclavicular lymph node metastasis. After three years, 48 cases were still survival. Conclusions Chest wall of large area skin defect repair methods for the treatment of patients with locally advanced breast cancer has a significant effect, can improve the quality of life of patients with locally advanced breast cancer, which can effectively relieve anxiety and depression of postoperative patients. Postoperative recurrence rate is low, and survival rate is high.
出处
《中国肿瘤临床与康复》
2015年第8期909-911,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
2012年度湛江市第四批非资助科技公关计划项目(2012C3104066)
关键词
乳腺肿瘤
生活质量
负性情绪
治疗结果
Breast neoplasms
Quality of life
Negative emotions
Treatment outcome
