摘要
目的探讨凝血功能指标检测对妊娠期高血压疾病(HDCP)的临床价值。方法选取2012年1月至2014年1月佛山市妇幼保健院妇产科收治的HDCP患者167例作为观察组,按HDCP诊断分级标准分为A、B、C 3组,另选广东佛山市妇幼保健院60例体检健康的妊娠孕妇作为对照组。测定D-二聚体(D-D)、凝血功能指标以及纤溶实验室指标。结果 A、B、C组与对照组比较,D-D、纤维蛋白原(FIB)、纤溶酶原激活抑制物-1(PAI-1)、组织纤溶酶原激活物(tPA)、血小板分布宽度(PDW)、平均血小板体积(MPV)值依次升高,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶原时间国际化标准比值(PT-INR)、抗凝血酶Ⅲ(AT-Ⅲ)、血小板计数(PLT)依次下降,差异有统计学意义(P<0.05);而各组间凝血酶时间(TT)比较,差异无统计学意义(P>0.05)。结论通过检测HDCP患者D-D、凝血功能指标以及纤溶实验室指标,有助于及时发现凝血功能异常,对HDCP的预防和治疗具有重要的临床价值。
Objective To discuss the clinical value of coagulation function indexes detectionin the patients with hypertensive disorders complicating pregnancy（HDCP）.Methods 167 patients with HDCP in our hospital from Jan.2011 to Jan.2014 were selected as the observation group and divided into the group A,B and C according to the HDCP diagnosis classification standard.Other 60 pregnant women undergoing the healthy physical examination at the same period in our hospital were selected as the control group.D-D,coagulation function indexes and fibrinolysis laboratory indexes were detected.Results Compared with the control group,the values of D-D,FIB,PAI-1,tPA,PDW,MPV in the group A,B and C were in turn increased,while the values of PT,APTT,PT-INR,AT-Ⅲand PLT count were in turn decreased,the differences were statistically significant（P〈0.05）.But TT had no statistical difference among various groups（P〉0.05）.Conclusion Detecting D-D,coagulation function indexes and fibrinolysis laboratory indexes conduces to discover the coagulant function abnormality and has an important clinical value for the prevention and treatment of HDCP.
出处
《检验医学与临床》
CAS
2015年第14期1992-1993,1996,共3页
Laboratory Medicine and Clinic
基金
广东省医学科研基金项目(2009030)
关键词
D-二聚体
凝血功能指标
纤溶实验室指标
妊娠期高血压
D-dimer
coagulation index
fibrinolysis index
hypertensive disorders complicating pregnancy
