摘要
[目的]观察茵陈蒿汤联合西药治疗湿热中阻型重度慢乙肝疗效。[方法]使用随机平行对照方法,将112例住院患者按就诊顺序号法简单随机分为两组。对照组56例1.2g还原型谷胱甘肽+100mg异甘草酸镁+10μg前列地尔+120μg促肝细胞生长素+100m L 5%GS或100m L NS,1次/d,静滴;HBV-DNA阳性予恩替卡韦,0.5mg/次,1次/d,口服。治疗组56例茵陈蒿汤(茵陈30g,大黄、栀子、白花蛇舌草、茯苓各15g,苍术10g,甘草6g),1剂/d,水煎200m L,早晚口服;西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、证候积分、总胆红素(TBil)、结合胆红素(DBil)、谷丙转氨酶(ALT)、白蛋白(ALB)、血胆碱酯酶(CHE)、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效22例,有效30例,无效4例,总有效率92.86%。对照组显效19例,有效25例,无效12例,总有效率78.57%。治疗组疗效优于对照组(P<0.05)。症候积分两组均有改善(P<0.05),治疗组改善优于对照组(P<0.01)。肝功能指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]茵陈蒿汤联合西药治疗湿热中阻型重度慢乙肝疗效满意,无严重不良反应,值得推广。
[Objective] To observe YCHT damp heat resistance combined with western medicine type of severe chronic hepatitis B treatment. [Methods]Randomized parallel-group method using the 112 cases of hospitalized patients with treatment order number method is simple and randomly divided into two groups. The control group 56 cases 1.2g Glutathione ＋ 100 mg magnesium isoglycyrrhizinate ＋ 10μg alprostadil＋120μg p HGF＋100m L 5% GS or 100 m L NS, 1 times/d, intravenous infusion; HBV-DNA positive i entecavir, 0.5mg/times, 1 times/d, orally. Treatment group 56 cases YCHT（Yinchen 30 g, Dahuang,Zhizi,Baihuasheshecao,Fu ling 15 g, Cangzhu 10 g, Gancao 6g）, 1 a/d, decoction 200 m L, sooner or later oral; Western medicine with the control groups. 28 d for a course of continuous treatment. Observation of clinical symptoms, symptom scores, total bilirubin（TBil）, bilirubin（DBil）, alanine aminotransferase（ALT）, albumin（ALB）, serum cholinesterase（CHE）, adverse reactions. A course of treatment to determine efficacy. [Results] Treatment group 22 cases, effective 30 cases, 4 cases, the total efficiency of 92.86%. The control group 19 cases markedly effective in 25 cases, 12 cases, the total efficiency 78.57%. Treatment group than in the control group（P〈0.05）. Symptom scores were improved in both groups（P〈0.05）, to improve the treatment group than the control group（P〈0.01）. Liver function were improved in both groups（P〈0.01）, the treatment group than the control group improved（P〈0.01）. [Conclusion]YCHT damp heat resistance combined with Western medicine treatment of moderate to severe chronic hepatitis type results were satisfactory, no side effects, it is worth promoting.
出处
《实用中医内科杂志》
2015年第5期144-146,共3页
Journal of Practical Traditional Chinese Internal Medicine
