摘要
口感是口腔给药系统(oral drug delivery system,ODDS)制剂处方研究设计的重要内容。传统的感官评价结果严重受制于受试者的个体差异,重现性较差,难以客观量化。鉴于此,介绍了其他学科领域口感评价的一些新技术、新方法,重点对药物在口腔中的味觉、黏附性、黏膜刺激性、沙砾感等新型评价方法进行了评述,以期为中药ODDS的质量评价及开发利用提供方法学借鉴。
Mouthfeel is an important part of preparation prescription study in oral drug delivery system. The results of traditional sensory evaluation are limited to individual differences of subjects, and own poor reproducibility. In this paper, some new technologies and evaluation methods were reviewed and commented, mainly including taste, adhesion, mucosal irritation, and grittiness, so as to provide methodology references for ODDS in traditional Chinese medicines and promote its progress.
出处
《中草药》
CAS
CSCD
北大核心
2015年第14期2167-2172,共6页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81403115,81274098)
国家基础科学人才培养基金(J13100340-19)
关键词
口腔给药系统
口感
评价方法
新技术
感官评价
oral drug delivery system
mouthfeel
evaluation methods
new technologies
sensory evaluation
