摘要
目的评价结核感染T细胞试验（T-SPOT.TB）在涂阴肺结核病诊断上的价值。方法利用T-SPOT.TB、TBDNA、TB-DOT 3种结核病诊断方法对112例确诊涂阴肺结核病患者和60例非结核病对照者分别进行检测。结果 T-SPOT.TB试验检测灵敏度为88.3%,TB-DNA、TB-DOT的灵敏度依次为25.9%、58.9%,与T-SPOT.TB试验相比,差异均有统计学意义（χ^2=86.6,P〈0.05;χ^2=23.3,P〈0.05）;T-SPOT.TB试验特异度为96.7%,显著高于TB-DOT（78.3%）,差异有统计学意义（χ^2=9.22,P〈0.05）。结论 T-SPOT.TB对涂阴肺结核病的敏感性和特异性都有明显的优势,可以作为涂阴肺结核病早期诊断的一种辅助检查手段,具快速准确的诊断价值。
Objective To evaluate the diagnostic value of Tuberculosis Infection in T Cell Test（T-SPOT.TB）for smear negative pulmonary tuberculosis.Methods Separately used T-SPOT.TB,TB-DNA,TB-DOT the three diagnostic methods for tuberculosis,separately detected with each method,112 smear negative pulmonary tuberculosis,and 60 non tuberculosis regarded as control group.Results The sensitivity of T-SPOT.TB,TB-DNA,TB-DOT in proper sequence were 88.3%,25.9%,58.9%.Contrasted to TB-DNA and TB-DOT,the differences were statistically significant（X^2=86.6,P〈0.01;X^2=23.3,P〈0.01）;the specificity of TSPOT.TB was 96.7%,significantly higher than TB-DOT（78.3%）,the differences were statistically significant（X2=9.22,P〈0.05）.Conclusion T-SPOT.TB has obvious advantages in sensitivity and specificity for smear negative pulmonary tuberculosis.It can be one auxiliary tool for smear negative pulmonary tuberculosis early diagnosis,provided with the value of fast and accurate.
出处
《国际检验医学杂志》
CAS
2015年第14期1975-1976,共2页
International Journal of Laboratory Medicine
基金
广东省汕头市科技重点攻关课题(2012165)
