摘要
目的探讨血清附睾蛋白4(HE4)、癌抗原125(CA125)单项及联合检测在子宫内膜异位症鉴别诊断中的应用价值。方法回顾性分析105例卵巢子宫内膜异位症患者(内异症组)、53例卵巢恶性肿瘤患者(卵巢恶性肿瘤组)、64例体检健康者(对照组)血清HE4与CA125水平。结果子宫内膜异位症组、卵巢恶性肿瘤组和对照组血清HE4阳性率分别为57.1%、90.6%和12.5%,三者比较差异有统计学意义(P<0.05)。子宫内膜异位症组、卵巢恶性肿瘤组和对照组血清CA125阳性率分别为44.8%、92.5%和14.1%,三者比较差异有统计学意义(P<0.05)。70pmol/L≤HE4<150pmol/L诊断子宫内膜异位症灵敏度、特异度分别为57.14%和53.86%;35U/mL≤CA125<150U/mL诊断子宫内膜异位症灵敏度、特异度分别为44.76%,61.24%;两者联合检测,灵敏度和特异度达70.32%和60.38%,三者比较差异有统计学意义(P<0.05)。结论血清CA125及HE4阳性率在子宫内膜异位症患者中明显升高,二者联合测定可进一步提高诊断的灵敏度。
Objective To investigate the application value of single or combined detection of HE4 and CA125in the differentiation diagnosis of endometriosis.Methods The detection results of serum HE4 and CA125levels in 105 cases of patients with ovarian endometriosis（endometriosis group）,53 cases of patients with（ovarian malignant group）tumor and 64 healthy women undergoing the healthy physical examination（control group）were performed the retrospective and statistical analysis.Results The positive rates of serum HE4 in the endometriosis group,ovarian malignant tumor group and control group were 57.1%,90.6% and 12.5%respectively with statistically significant difference among them（P〈0.05）.The positive rates of serum CA125 in the above 3groups were 44.8%,92.5%and 14.0%respectively,and the differences were statistically significant（P〈0.05）.（3）The sensitivity and specificity of 70pmol/L≤HE4150pmol/L for diagnosing endometriosis were 57.14%and 53.86%respectively,which of 35U/mL≤CA125〈150 U/mL for diagnosing endometriosis were 44.76% and 61.24%.But the sensitivity and specificity of their combined detection were 70.32% and 60.38%.There were statistically significant differences of sensitivity and specificity among single and combined detecion of HE4 and CA125（P〈0.05）.Conclusion Serum HE4 and CA125levels are significantly elevated in the patients with endometriosis,their combined detection could further raise the sensitivity for diagnosing endometriosis.
出处
《国际检验医学杂志》
CAS
2015年第14期2075-2076,共2页
International Journal of Laboratory Medicine
