摘要
目的比较大剂量和小剂量丙种球蛋白联合强的松治疗特发性血小板减少性紫癜（ITP）的效果,寻求效价比高的治疗方案。方法选择我院儿科2010年3月~2014年5月住院的64例特发性血小板减少性紫癜患儿,采用隐匿数字随机法分为两组,A组32例患儿给予400mg/（kg·d）丙种球蛋白治疗5d后口服强的松,B组32例患儿给予200mg/（kg·d）丙种球蛋白治疗5d后口服强的松,用药后每天检测血小板计数,记录患儿血小板上升时间、止血时间、达峰值时间和峰值,对疗效进行比较。结果两组患儿治疗后平均血小板上升时间、平均止血时间、血小板平均峰值比较差异无统计学意义（P〉0.05）;A组患儿平均达峰值时间短于B组,差异具有统计学意义（P〈0.05）。A组显效率、有效率和进步率分别为75.00%、18.75%、6.25%,总有效率为93.75%;B组显效率、有效率和进步率分别为68.75%、21.88%、9.37%,总有效率为90.63%,差异无统计学意义（P〉0.05）。结论小剂量丙种球蛋白联合强的松是治疗特发性血小板减少性紫癜效价比高的治疗方案,可快速升高血小板和控制出血。
Objective To compare the efficacy of low dose and high dose gamma globulin combined with prednisone in the treatment of idiopathic thrombocytopenic purpura for obtaining a better cost-effect ratio treatment scheme. Methods Between March 2010 and May 2014 atotal of 64 pediatric patients with idiopathic thrombocytopenic purpura cared at Pediatrics Department of our hospital were enrolled in this study,a hidden random number table method was used to allocate the patients to two groups.Thirty-two cases in group A were given 400 mg/（kg·d）gamma globulin for 5days,after that they received oral prednisone.Thirty-two cases in group B were given 200mg/（kg·d）gamma globulin for 5days,after that they received oral prednisone,after drug administration,platelet count was measured,and the platelet elevating time,mean hemostasis time,time to platelet peak and the platelet value were all recorded every day.The efficacy rate was compared between the two groups. Results After treatment,comparison of mean platelet elvating time,average hemostasis time,mean platelet peak value between the two groups of pediatric children showed no significant differences（P〉0.05）.Group A patients had shorter average peak time than group B,group paired comparison yielded statistical difference（P〈0.05）.The significant efficiency,efficiency and progress rates of group A were 75.00%,18.75%,6.25%,respectively,the total effective rate was 93.75%;the significant efficiency,efficiency and progress rates of group B were 68.75%,21.88%,9.37%,respectively,the total effective rate was 90.63%,group paired comparison yielded no statistically significant difference（P〉0.05）.Conclusion Low dose gamma globulin combined with prednisone in treatment of idiopathic thrombocytopenic purpura can obtain high potency ratio,can quickly increase platelet and control of hemorrhage.
出处
《右江民族医学院学报》
2015年第4期589-590,592,共3页
Journal of Youjiang Medical University for Nationalities
