摘要
目的:应用光学相干断层成像技术(OCT)测量比较阻塞性睡眠呼吸暂停(OSA)患者和正常对照人群的视网膜神经纤维层(RNFL)厚度,探讨视网膜神经纤维层厚度的减少与阻塞性睡眠呼吸暂停的相关性。方法:计算机检索国内外数据库中关于使用OCT技术测量OSA患者与正常对照人群的RNFL厚度的临床对照试验、同时筛检纳入文献的参考文献。对符合纳入和排除标准的试验用Stata11.0软件进行Meta分析。结果:纳入10项研究,共1488眼进行Meta分析。结果显示OSA患者的平均、上侧、鼻侧、下侧RNFL厚度相较正常对照组明显减少,加权均数差值分别为[-2.97,95%CI:(-4.65^-1.30),P<0.01]、[-3.05,95%CI:(-4.93^-1.17),P=0.002]、[-3.81,95%CI:(-6.95^-0.68),P=0.02]和[-4.16,95%CI:(-7.63^-0.68),P=0.02]。结论:OSA患者相较正常人群出现了明显的RNFL厚度的减少,因此我们建议OSA患者需要常规进行OCT的RNFL厚度检查。
AIM：To investigate the difference of retinal nerve fiber layer（RNFL） thickness measured with OCT between obstructive sleep apnea（OSA） patients and normal people and discuss the relativity between decresse of RNFL and OSA.METHODS：The articles on the association of RNFL thickness and OSA were retrieved by searching international and national databases.The qualified articles were assessed by Meta- analysis with Stata11.0software.RESULTS：Totally 10 studies enrolled 1 488 eyes were included in the Meta- analysis.The results of Meta-analysis showed that in OSA patients,there was a significant average RNFL thickness reduction compared with the control group.There were significant differences in superior,nasal and inferior RNFL thickness between the two groups.WMD with a 95%Cl were[-2.97,95%C/：（-4.65--1.30）,P0.01],[-3.05,95%Cl：（-4.93--1.17）,P=0.002],[-3.81,95%C/：（-6.95--0.68）,P=0.02],[- 4.16,95%Cl：（- 7.63--0.68）,P = 0.02]respectively..CONCLUSION：RNFL thickness is reduced in OSA patients compared with the control group.OCT may become a standard part of the evaluation of patients in OSA.
出处
《国际眼科杂志》
CAS
2015年第8期1340-1343,共4页
International Eye Science
