摘要
目的 探讨鸦胆子油乳联合顺铂腹腔灌注治疗卵巢癌的效果。方法 选取2014年1月-2015年2月在本院就诊的卵巢癌患者127例,将其根据治疗方法分为治疗组（n=74）和对照组（n=53）。对照组给予单纯顺铂腹腔灌注治疗,治疗组在对照组基础上给予联合鸦胆子油乳进行局部化疗,化疗3周后,评估两组的腹水疗效、临床症状总改善率、生活质量提高率和毒副反应发生情况。结果 腹水疗效的比较：治疗组的有效率为83.8%,明显高于对照组的62.3%（P〈0.05）;治疗组的临床症状总改善率为90.5%,明显高于对照组的69.8%,患者生活质量评分提高率为78.4%,明显高于对照组的62.3%（P〈0.05）;治疗组的白细胞下降发生率为54.1%,对照组为71.7%,两组差异有统计学意义（P〈0.05）。结论 鸦胆子油乳联合顺铂腹腔灌注化疗是一种安全、有效的卵巢癌治疗方法。
Objective To study the effect of bruceolic oil emulsion combined with cisplatin for peritoneal perfusion treating ovarian cancer. Methods From January 2014 to February 2015,127 patients with ovarian cancer treated in our hospital were selected and they were divided into treatment group （n=74） and control group （n=53） according to the treatment method.Control group was treated with simple cisplatin for peritoneal perfusion,while treatment group was treated with bruceolic oil emulsion for local chemotherapy on the basis of control group.The curative effect of ascites,the total improvement rate of clinical symptom,the improvement rate of life quality and the incidence of toxic side reaction in two groups were evaluated. Results The comparision of curative effect of ascites：the effective rate of treatment grouP （83.8%） was obviously higher than that of control group （62.3%） （P〈0.05）;the total improvement rate of clinical symptom of treatment group （90.5%） was obviously higher than that of control group （69.8%）,the improvement rate of life quality treatment group （78.4%） was obviously higher than that of control group （62.3%） （P〈0.05）;the rate of white cell decreasing in treatment group was 54.1%,while it was 71.7% in control group,and there was a statistical difference between two groups, （P〈0.05）. Conclusion Bruceolic oil emulsion combined with cisplatin for peritoneal perfusion is a safe and effective method for treatment of ovarian cancer.
出处
《中国当代医药》
2015年第20期115-117,共3页
China Modern Medicine
基金
广东省自然科学基金(2014A030310029)
关键词
鸦胆子油乳
顺铂
卵巢癌
腹腔灌注
Bruceolic oil emulsion
Cisplatin
Ovarian cancer
Peritoneal perfusion
