摘要
目的观察多西他赛与顺铂在放射疗治疗中晚期食管癌的疗效及不良反应。方法将70例老年食管癌患者随机分为两组。多西他赛组35例放射治疗联合多西他赛增敏治疗,顺铂组35例采用放射疗联合顺铂增敏治疗。比较观察2组的疗效和不良反应。结果多西他赛组和顺铂组完全缓解率分别为37.1%、34.2%,差异无统计学意义(P>0.05);两年总生存率比较差异无统计学意义(P>0.05)。两组不良反应中恶心、呕吐方面多西他赛组好于顺铂组,差异有统计学意义(P<0.05)。在骨髓抑制、放射性肺炎、放射性食管炎方面差异无统计学意义(P>0.05)。结论放射治疗联合多西他赛增敏治疗与顺铂增敏治疗疗效相近,且不增加不良反应。
Objective To explore the efficacy and toxicities of radiotherapy combined with docetaxel or cisplatin in the treatment of advanced esophageal carcinoma, Methods Seventy cases of esophageal carcinoma were randomly divided into two groups： 35 cases of a group received radiotherapy weekly docetaxel, 35 cases of the another group received radiotherapy combined with weekly cisplatin. After treatment, the efficacy and toxicities of the two groups were observed comparatively. Results There was no significant difference in the short-term response rate and 2-year survival rates between two groups（P〉0.05）. There was no significant difference in the incidence of myelosuppression, radiation-induced esophagitis and radiation-induced pneumonia between the two groups. The incidences of nausea, Vomiting was significantly lower in the docetaxel group than in the eisplatin group. Conclusion Radiotherapy combined with docetaxel is effective and well-tolerated in patients with locally advanced esophageal carcinoma.
出处
《中国医药指南》
2015年第20期1-3,共3页
Guide of China Medicine
关键词
放射治疗
多西他赛
顺铂
食管癌
Radiotherapy
Docetaxel
Cisplatin
Esophageal cancer
