摘要
目的:观察氟哌噻吨美利曲辛治疗脑卒中后抑郁症和(或)焦虑症的临床效果。方法:选取2011年10月—2014年10月120例脑卒中后有抑郁症和(或)焦虑症的患者,以随机数字表法分为治疗组和对照组各60例。在常规治疗的基础上,治疗组患者给予氟哌噻吨美利曲辛片1日2~4片,对照组给予阿米替林1次1~2片、1日3次,疗程8周。采用汉密尔顿抑郁量表( HAMD)、汉密尔顿焦虑量表( HAMA)、临床疗效总评量表( CGI)、治疗副反应量表( TESS)评价2种药物的临床疗效和不良反应,采用生活质量综合评定问卷( GQOLI)评价患者的生活质量。结果:治疗8周后,治疗组患者HAMD、HAMA总分均较治疗前显著下降(P<0.01),不良反应较对照组少(P<0.01),CGI、GQOLI评分有所提高。结论:应用氟哌噻吨美利曲辛治疗脑卒中后抑郁和(或)焦虑症,疗效确切,且使用方便,毒副作用小。
OBJECTIVE:To evaluate the clinical efficacy of Flupentixol Melitracen tablets for post-stroke depression and( or) anxiety disorder.METHODS: Between Oct.2011 and Oct.2014, a total of 120 patients with post-stroke depression and( or) anxiety disorders were randomized to either treatment group or control group of 60 cases each.The treatment group received add-on Flupentixol Melitracen tablets(2-4 tablets daily) while the control group received amitriptyline (1-2 tablets/time multiply three times daily) for 8 weeks.Hamilton Depression Rating Scale ( HAMD ) , Hamilton Anxiety Scale ( HAMA ) , Clinical Global Impression Scale ( CGI ) and Treatment Emergent Sympton Scale ( TESS) were employed for evaluation of the efficacy and adverse drug reactions of two drugs;General Quality Of Life Inventory ( GQOLI) was used for evaluation of the quality of life of patients.RESULTS:After 8-week treatment, the total score in HAMD and HAMA in the treaetment group were significantly lower than before treatment ( P〈0.01 ) and the adverse reactions were less in the treaetment group than in the control group ( P〈0.01 ) , CGI score and GQOLI score increased than before treatment.CONCLUSIONS:Flupentixol Melitracen is safe and effective and convinent to use in treatment of post-stroke depression and ( or) anxiety disorder.
出处
《中国医院用药评价与分析》
2015年第5期590-592,共3页
Evaluation and Analysis of Drug-use in Hospitals of China