摘要
目的:比较西酞普兰与舍曲林治疗中国老年抑郁症患者的疗效及不良反应。方法:通过计算机检索1994—2013年国内关于西酞普兰与舍曲林治疗老年抑郁症的随机对照研究文献,应用系统评价方法对检索到的3篇随机对照研究文献进行定量综合分析。结果:西酞普兰疗效与舍曲林比较差异无统计学意义(P>0.05)。舍曲林组发生头昏、便秘者较西酞普兰组多见,差异具有统计学意义(P<0.01)。其他不良反应发生率比较差异无统计学意义(P>0.05)。结论:西酞普兰与舍曲林治疗中国老年抑郁症患者的疗效相似,西酞普兰较舍曲林不良反应轻微。
OBJECTIVE：To compare the clinical efficacy and the adverse reactions between citalopram and sertrline in treatment of Chinese senile patients with depression.METHODS：A total of 3 randomized controlled trials comparing citalopram and sertraline in treatment of senile patients with depression retrieved in domestic literature from 1994 to 2013 were subjected to a comprehensive quantitative analysis.RESULTS： There was no significant difference on clinical efficacy between citalopram and sertraline （ P〉0.05 ） .The incidence rates of dizziness and constipation in sertraline group were significantly higher than in citalopram group （P〈0.05）.There were no significant differences in incidence rates of other adverse reactions between the two groups （ P 〉0.05 ） .CONCLUSIONS： Eitalopram is as effective as sertraline but with milder adverse drug reactions than the latter in treatment of depression in Chinese senile patients.
出处
《中国医院用药评价与分析》
2015年第6期769-772,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
