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心脑血管系统缺血适应机制的研究进展

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摘要 自1986年Murry等[1]率先制作缺血预适应（ischemic preconditioning,IPC）动物模型及进行相关研究后,随后有学者报道了远隔缺血预适应（remote ischemic preconditioning,RIPC）、缺血后适应（ischemic postconditioning,Ipost C）、
作者 侯城北 吉训明
机构地区 首都医科大学宣武医院循证医学中心 首都医科大学宣武医院神经外科
出处 《中国脑血管病杂志》 CAS CSCD 北大核心 2015年第7期380-384,共5页 Chinese Journal of Cerebrovascular Diseases
关键词 缺血适应 心脑血管系统 机制 综述
分类号 R54 [医药卫生—心血管疾病] R743 [医药卫生—神经病学与精神病学]
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  • 1Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium [ J ]. Circulation, 1986,74 (5) : 1124-1136.
  • 2Hess DC, Hoda MN, Bhatia K. Remote limb perconditioning and postconditioning: will it translate into a promising treatment for acute stroke? [ J ]. Stroke, 2013,44 (4) : 1191-1197.
  • 3Vinten-Johansen J, Shi W. Perconditioning and postcondi- tioning: current knowledge, knowledge gaps, barriers to adoption, and future directions [ J ]. J Cardiovasc Pharmacol Ther,2011,16(3/4) :260-266.
  • 4Armstrong S, Downey JM, Ganote CE. Preconditioning of isolated, rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor [ J 1. CardiovascRes,1994,28( 1 ) :72-77.
  • 5Baines CP, Zhang J, Wang GW, et al. Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PK Cepsilon-MAPK interactions and differential MAPK activation in PKC epsiloninduced cardioprotection [ J ]. Circ Res, 2002, 90(4) :390-397.
  • 6Matsumoto-Ida M, Akao M, Takeda T, et al, Real-time 2-photon imaging of mitochondrial function in peffused rat hearts subjected to ischemia/reperfusion [ J ]. Circulation, 2006,114 (14) :1497-1503.
  • 7Takaoka A, Nakae I, Mitsunami K, et al. Renal ischemia/ reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits : effects of ' remote preconditioning' [ J]. J Am Coll Cardiol, 1999,33 (2):556-564.
  • 8Zhou K,Yang B,Zhou XM, et al. Effects of remote ischerrfic preconditioning on the flow pattern of the left anterior descending coronary artery in normal subjects [ J ]. Int J Cardiol,2007,122 (3) :250-251.
  • 9Kharbanda R, Peters M, Walton B, et al. Ischemic preeonditioning prevents endothelial injury and systemic neutrophil activation during ischemia reperfasion in humans in vivo [ J ]. Am Heart Assoeiation, 2001,103 (12) :1624-1630.
  • 10Shimizu M, Sexena P, Konstantinov IE, et al. Remote isehemic preconditioning decreases adhesion and seleetively modifies functional responses of human neutrophils [ J]. J Surg Res,2010,158 ( 1 ) : 155-161.
中国脑血管病杂志
2015年 第7期

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