摘要
目的：探讨幽门螺杆菌（Hp）感染对儿童生长发育及营养状况的影响。方法选取2010年3月至2012年9月在浙江大学金华医院初次就诊并确诊为Hp感染的患儿174例，同时选取同期来医院体检的年龄、性别与研究对象相当的100名儿童作为健康对照组。 Hp感染患儿给予一线抗Hp治疗，并随访2年。采用t检验、重复测量方差分析及LSD检验比较Hp感染患儿与健康对照儿童生长发育及营养状况基线值，以及抗Hp感染根除治疗组与复发组随访两年的生长发育及营养状况。结果174例Hp感染患儿中，确诊真性性早熟2例，中途放弃治疗者6例，失访8例，最终共有158例患儿完成研究。其中，128例患儿完成治疗后转阴，30例患儿复发。158例Hp感染患儿的身高、体质量，以及外周血中血红蛋白（Hb）、白蛋白（Alb）、血尿素氮（ BUN）、铁（Fe）及锌（Zn）均显著低于健康儿童（t＝2.674、1.657、12.709、3.662、4.227、4.210、14.820，P值均＜0.05）。Hp感染根除组随访1年与2年时测定的身高、体质量，以及外周血中Hb、Alb、BUN、Fe及 Zn均升高，与基线比较差异均有统计学意义（F＝8.350、14.998、50.875、37.584、22.701、8.295和41.791，P值均＜0.01）；而30例复发患儿随访1年与2年时测定的外周血中Hb、Alb、BUN及Fe与基线比较差异均无统计学意义（ F＝1.826、1.659、2.613、2.495，P值均＞0.05）。随访2年时Hp感染根除组身高、体质量以及外周血Alb、BUN、Fe、Zn增长值均显著高于复发组（t＝7.86、5.17、8.80、5.92、2.17、7.28， P值均＜0.05）。结论 Hp感染会影响患儿的生长发育和营养状况，根除Hp感染有助于改善儿童生长发育与营养状况。
Objective To investigate the effect of Helicobacter pylori （ Hp） infection on the growth and nutritional status in children.Methods A total of 174 children with Hp infections were collected from Jinhua Hospital of Zhejiang University during March 2010 to September 2012, and 100 healthy children were also enrolled as the controls.The differences in age and gender between Hp-infected group and control group were not significant.All Hp-infected children were given first-line anti-Hp therapy and followed-up for two years.t test, repeated measure ANOVA and LSD test were used to analyze the growth and nutritional status between Hp infected children and healthy controls, as well as between HP-infection eradication group and relapse group.Results Among 174 Hp-infected children, 2 were diagnosed as true precocious puberty, 6 abandoned treatment and 8 were lost to follow-up.Among 158 children who completed the study, Hp infection was eradicated in 128 （eradication group）, and relapsed in 30 （relapse group）.The height,＆amp;nbsp;weight, peripheral levels of hematoglobin （ Hb） , Albumin （ Alb） , blood urea nitrogen （ BUN） , Fe and Zn in 158 Hp-infected children at the baseline were significantly lower than those in the healthy control group （t=2.674, 1.657, 12.709, 3.662, 4.227, 4.210 and 14.820, all P 〈0.05）.The height, weight, peripheral levels of Hb, Alb, BUN, Fe and Zn in eradication group were increased in 1-and 2-year of the follow-up （F=8.350, 14.998, 50.875, 37.584, 22.701, 8.295 and 41.791, all P〈0.01）, while there were no significant increase in the levels of Hb, Alb, BUN and Fe in the relapse group （F=1.826, 1.659, 2.613 and 2.495, all P〉0.05）.In the second year of the follow-up, the increases of Alb, BUN, Fe and Zn in eradication group were significantly higher than those in the relapse group （ t=7.86, 5.17, 8.80, 5.92, 2.17 and 7.28, all P 〈0.05）.Conclusion Hp infection may affect the growth and nutritional status of children, and the eradication of Hp infection may help to improve the development and nutritional status of the children.
出处
《中华临床感染病杂志》
CAS
2015年第3期258-262,共5页
Chinese Journal of Clinical Infectious Diseases
基金
浙江省金华市科学技术研究计划重点项目（2012-03-012）
关键词
螺杆菌
幽门
儿童
生长和发育
营养状况
Helicobacter pylori
Child
Growth and development
Nutritional status
