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胃蛋白酶原在胃癌诊断中的临床价值 被引量:6

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摘要 目的探讨血清胃蛋白酶原(PG)水平在胃癌诊断中的临床价值。方法选择经胃镜活检和病理形态学确诊的浅表性胃炎组68例、慢性萎缩性胃炎组66例、胃癌组65例和体检健康组60例。采集所有对象静脉血分离血清,检测血清胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ),并计算PGⅠ/PGⅡ比值(PGR)。结果胃癌组PGⅡ、PGR水平和其它三组比较差异均有统计学意义(P<0.05或P<0.01);PGⅠ、PGⅡ、PGR诊断胃癌临界值分别为72.95μg/L、8.95μg/L、4.08,ROC曲线下面积分别为0.613、0.817、0.827,敏感度分别为53.4%、87.9%、65.5%,特异度分别为88.2%、56.7%、84.4%,准确度分别为61.3%、81.7%、82.7%,联合PGⅡ和PGR诊断胃癌的ROC最大曲线下面积为0.839,敏感度、特异度和准确度分别为84.5%、72%和83.9%。结论联合检测PGⅡ和PGR可提高胃癌诊断的准确性,临界值为PGⅡ≥9.0μg/L且PGR≤4.58,可为本地区体检高危人群的筛查提供依据。
机构地区 浙江省中医院
出处 《浙江实用医学》 2015年第3期175-176,190,共3页 Zhejiang Practical Medicine
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