摘要
目的观察结缔组织病致肺间质病变的临床表现特点、生理指标变化及干预效果。方法对我院2010年3月~2013年10月所收治103例结缔组织病致肺间质病变住院患者进行研究,观察患者临床表现并进行血气分析,结合实际情况予以相应治疗,观察干预结果。结果 CTD-ILD患者主要临床表现包括呼吸系统症状及全身症状两个方面,其中DM/PM主要症状以发热、呼吸困难为主,SLE以呼吸困难为主,RA为咳嗽,p SS以呼吸系统症状为主。所有患者中,咳嗽、呼吸困难、皮肤损害、发热等症状患者较多。103例患者中,36.9%血气分析结果正常,34.9%患者为低氧血症,23.3%为Ⅰ型呼吸衰竭,Ⅱ型呼吸衰竭患者较少,所占比例仅为4.9%。DM/PM、SLE、RA、p SS、SSc不同类型疾病血气分析结果存在较大差异。103例患者均应用激素或免疫抑制剂进行治疗,结合患者实际情况的不同,治疗方案包括泼尼松单独治疗、泼尼松联合环磷酰胺、泼尼松联合羟氯喹、泼尼松联合氟米特、泼尼松联合甲氨蝶呤等。其中94例患者各临床症状,明显好转,9例患者病情未得到明显控制,无死亡病例。结论 CTD-ILD临床表现以呼吸系统症状及全身症状两方面为主,患者易合并低氧血症,激素联合免疫抑制剂为目前最有效治疗方法,效果较好。
Objective To observe the clinical performance characteristics, physiological changes and the effect of intervention of pulmonary interstitial disease by connective tissue disease. Methods 103 cases of connective tissue disease induced interstitial lung disease patients in our hospi- tal in March 2010-October 2013 were studied, observation of patients with clinical manifestation and analyzed blood gas, combined with the actual situation to corresponding treatment, observed the result of intervention. Results In CTD-ILD patients, the main clinical manifestations included two aspects of respiratory symptoms and systemic symptoms, including the main symptoms of DM/ PM with fever, shortness of breath, SLE to shortness of breath, RA was cough, pSS with respira- tory symptoms. All patients mostly with symptoms in patients like cough, breathe in difficulty, skin lesions, fever and other. In 103 patients, 37.9% had normal blood gas results, 34% patients had hypoxemia, 23.2% as type I respiratory failure, fewer patients with type II respiratory failure, the proportion was only 4.9%.There was great variation of DM/PM, SLE, RA, pSS, SSc and blood gas analysis results of different types of diseases.Conclusions The clinical manifestations of CTD- ILD in two aspects of respiratory symptoms and systemic symptoms, patients easily complicated with hypoxemia, hormone combined with immunosuppressive is the most effective method of treat- ment,, the effect is better.
出处
《现代诊断与治疗》
CAS
2015年第10期2161-2163,共3页
Modern Diagnosis and Treatment
关键词
结缔组织
肺间质病变
临床表现
干预
Connective tissue
Interstitial lung disease
Clinical manifestation
Intervention
