摘要
目的探讨不同方案来曲唑(LE)对不明原因不孕患者促排卵的效果。方法将47例患者随机分成3组,A组(对照组)15例给予来曲唑5.0 mg/d,连服5 d;B组12例,于月经周期的第3天一次性顿服来曲唑20 mg;C组20例,给予来曲唑+尿促性腺素(HMG)治疗。分析比较各组促排卵方案的临床效果。结果 C组较其他2组有更好的优势卵泡率、排卵率及临床妊娠率,但差异无统计学意义(P>0.05)。3组患者注射绒毛膜促性腺激素(HCG)日子宫内膜厚度和宫颈黏液评分比较差异均不显著(P>0.05)。3组均未发生卵巢过度刺激综合征(OHSS)。结论来曲唑对于不孕患者促排卵具有一定优势,一次性顿服方案,可能是不孕患者促排卵更好的选择。在LE的基础上给予HMG治疗,可以提高治疗效果。
Objective To compare the effects of letrozole（LE） with different methods in patients with unexplained infertility.Methods The patients were randomized into 5.0 mg dose of LE（A group,15 patients）daily for5 d,treated by 20 mg LE（B group,12 patients）in the third of menstrual cycle or treated by Lehman menopausal gonadotropin（HMG）（C group,20 patients）.The effects of ovulation induction in the three groups were compared.Results The rate of higher average dominant follicle numbers on the day of human chorionic gonadotropin（HCG）,ovulation rate and clinical pregnancy rate in C group was higher than in other groups,but there was no significant difference in the three groups. The endometrial thickness on HCG day and cervical mucus scores in the three groups were no significant difference（P0.05）.No ovarian hyperstimulation syndrome（OHSS）occurred in the three groups.Conclusion LE for ovulation effect of infertility patient has certain advantage. It＇s best choose treated by 20 mg LE in the third of menstrual cycle for patients with unexplained infertility. Letrozole combined with HMG may improved the effect of ovulation induction.
出处
《基层医学论坛》
2015年第20期2737-2739,共3页
The Medical Forum
基金
钦州市科技攻关项目(20114203)
关键词
不孕
不明原因
促排卵
来曲唑
Infertility Unknown causes Ovulation induction Letrozole
