摘要
目的分析北京市成人高危人群乙肝疫苗免疫接种成本效果。方法采用马尔科夫模型估计对北京市医务人员及表面抗原阳性的成人的配偶及其家庭成员进行乙肝疫苗接种的成本效用比,并对影响成本效用的因素进行敏感性分析。结果如果采用国产试剂筛查乙肝五项,并按照20μg国产乙肝疫苗接种3剂,接种率100%,则针对北京市医务人员接种每获得一个质量调整生存年数(quality-adjusted life-year,QALY)节省费用90.17元;针对乙肝表面抗原阳性者家庭成员接种乙肝疫苗每获得的一个QALY节省费用2 470.10元。不同的筛查方案、接种率、贴现率和QALY权重下,该结论不变。结论北京市目前推荐的乙肝疫苗高危人群接种可获得较好的成本效用比,有必要提高上述人员乙肝疫苗接种率,从而最终降低北京市乙肝发病率和死亡率。
Objective To investigate the cost-effectiveness of hepatitis B（HB） vaccination strategy for high risk adults in Beijing,China.Methods A Markov model was developed for cost-utility analysis of different hepatitis B vaccine immunization strategy in health professionals and the adults who had close household contact with HBV carries,and sensitivity analyses were conducted to determine the impact of varying parameter values.Results Under an assumption of using domestic agents for screening and 3-dose 20 μg recombinant HB vaccination with 100% coverage and annual discount rate of3%,predicted cost-utility ratio was-90.17 RMB / quality-adjusted life year（QALY） for health professionals and-2 470.10 RMB / QALY for the adults who had the close household contact.The same conclusion was drawn with different screening and vaccination strategies,vaccine rate,discount rate,and the confidence interval of QALY weight.Conclusions HB vaccination of health professionals and the adults who have close household contact with HBV carries is cost-effective and vaccination among high risk healthy adults in Beijing is recommended,to reduce the morbidity and mortality of HBV.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2015年第7期730-734,共5页
Chinese Journal of Disease Control & Prevention
基金
"十二五"国家科技重大专项(2012ZX10004904)
关键词
肝炎
乙型
免疫
流行病学研究
Hepatitis B
Immunity
Epidemiologic studies
