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脑利钠肽与慢性心力衰竭合并OSAHS患者预后的相关性分析 被引量:3

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摘要 目的:探讨脑利钠肽与慢性心力衰竭(CHF)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者预后的相关性。方法纳入CHF患者98例,根据多道睡眠图监测分为对照组(CHF组)(50例)及观察组(CHF合并OSAHS组)(48例),测定血气分析、血脂、血糖、肝、肾功能、脑利钠肽(BNP)水平以及心脏彩超检查。对观察组随访1次/3个月,共18个月。记录症状变化、心律失常及死亡等临床事件的情况,并测定血气分析、血浆BNP、心脏彩超。结果入院时与对照组比较,观察组的左室舒张末期内径、BNP水平较高,而左室射血分数较低(P〈0.05)。对观察组进行18个月的随访发现,左室射血分数逐渐降低,左室舒张末期内径、BNP水平逐渐升高,并且血浆BNP与左室射血分数呈负相关(r=-0.29,P〈0.05),而与左室舒张末期内径呈正相关(r=0.31,P〈0.05);观察组的临床事件发生率明显较对照组高,且BNP的水平与临床事件的发生呈正相关(r=0.18,P〈0.05)。结论 CHF合并OSAHS患者的预后明显较单纯心力衰竭患者差,血浆BNP可能对该类患者的预后具有预测的作用。
出处 《浙江临床医学》 2015年第8期1368-1370,共3页 Zhejiang Clinical Medical Journal
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参考文献5

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