摘要
目的评价静注人免疫球蛋白在小儿胆道闭锁行Kasai术后的应用价值。方法利用HIS抽取2013年我院小儿外科行Kasai手术的胆道闭锁患儿,统计年龄分布及性别比例。按术后是否给予静注人免疫球蛋白将患儿分为2组,进行术后12个月的门诊以及电话随访,对比分析两组术后胆管炎的发生情况。对静注人免疫球蛋白的用量分布、疗程、用药时机等方面进行统计。结果 2013年我院小儿外科共有54例胆管闭锁患儿行Kasai术,其中男31例,女23例;发生年龄以2个月龄为多见。术后使用静注免疫球蛋白24例,未使用30例,术后胆管炎的发生率分别为29.17%与33.33%(P>0.05)。静注免疫球蛋白组Kasai术后胆管炎的发生时间较长(P<0.05)。使用静注人免疫球蛋白的单次剂量均为2.5 g;疗程分布以单次最多(9例),疗程≤3 d者占70.83%(17/24);给药时机以术后第1天和第2天最多,占62.50%(15/24)。结论 Kasai术后静注免疫球蛋白可在一定程度上提高机体的免疫力,延缓胆管炎的发生。
Objective To evaluate the value of intravenous injection of human immunoglobulin in the treatment of pediatric biliary atresia（ BA） after Kasai procedure（ KP）. Methods The biliary atresia（ BA） children underw ent KP in pediatric surgery of our hospital w ere chosen using Hospital Information System（ HIS）,and the distribution of age and proportion of gender w ere analyzed. All the patients w ere divided into 2 groups according to w hether the human immunoglobulin w as injected after operation. The incidence of cholangitis in the tw o groups after discharged w as compared by follow-up of outpatient and telephone for 12 months. The dosage distribution,course of treatment and time of intravenous injection of human immunoglobulin w ere recorded. Results There w ere 54 BA cases underw ent KP in our hospital in 2013,including 31 males and 23 females w ith age of 2 months mostly. 54 cases w ere divided into intravenous immunoglobulin group（ observation group,n = 24） and control group（ n = 30）. The incidences of cholangitis in observation group and control group w ere 29. 17% and 33. 33% respectively,no significant difference w as found（ P〈0. 05）. The occurrence of cholangitis after KP in observation group w as delayed（ P〈0. 05）. The dosage of intravenous injection of human immunoglobulin w as 2. 5 g. There w ere 9 cases w ith the course of 1 d,8 cases w ith the course of 2d,and 17 cases（ 70. 83%） w ith the course≤3 d. Most of the patients w as injected at the first day and second day after operation（ 62. 50%）. Conclusion Intravenous immunoglobulin could increase the human immunity,delay the occurrence of cholangitis after Kasai.
出处
《实用药物与临床》
CAS
2015年第7期804-807,共4页
Practical Pharmacy and Clinical Remedies
基金
广西壮族自治区中医药科技项目(GZZJ13-17)
