摘要
目的测定市售维C银翘片对乙酰氨基酚的体外溶出度,反映产品的内在质量。方法采用高效液相色谱法,根据我国药典和日本橙皮书对对乙酰氨基酚片的体外溶出要求,分别在5种介质中测定其体外溶出度。结果 5个厂家的维C银翘片对乙酰氨基酚片的体外溶出均达不到要求。结论维C银翘片应增加体外溶出度检测,以提高产品质量。
Objective To determine the dissolution of paracetamol from 5 different brands of Vitamin C Yinqiao Tablets and to reflect the intrinsic quality. Methods The dissolution w as determined in 5 different medium using HPLC according to the dissolution requirements of paracetamol tablets. Results The dissolution of Vitamin C Yinqiao Tablets from 5 factories failed to achieve the standards of Ch. P. and orange book. Conclusion The dissolution should be detected so as to improve the quality of Vitamin C Yinqiao Tablets.
出处
《实用药物与临床》
CAS
2015年第7期823-825,共3页
Practical Pharmacy and Clinical Remedies
基金
江苏省大学生实践创新训练计划项目(201413842015Y)
