摘要
目的探讨瑞舒伐他汀对冠心病合并左心功能不全患者的临床疗效。方法选择2013年1月-2014年6月本院收治的血脂正常冠心病合并左心功能不全[左心室射血分数（LVEF）〈40%]的患者100例,随机分为治疗组50例和对照组50例,对照组给予常规治疗,治疗组在常规治疗的基础上加用瑞舒伐他汀10 mg/次,每晚1次,疗程6个月,比较两组治疗前、治疗6个月的血脂、LVEF、心绞痛发作频率。结果治疗6个月治疗组总胆固醇、三酰甘油、低密度脂蛋白胆固醇均低于治疗前,高密度脂蛋白胆固醇高于治疗前,差异有统计学意义（P〈0.05）;治疗组治疗前、治疗6个月LVEF分别为（36±7）%、（52±9）%,对照组分别为（32±8）%、（42±7）%,治疗组治疗6个月LVEF高于治疗前,且高于对照组（P〈0.05）;治疗组治疗6个月心绞痛发作频率低于治疗前及对照组,两组比较,差异有统计学意义（P〈0.05）。结论对血脂正常冠心病合并心功能不全的患者,在常规治疗的基础上加用瑞舒伐他汀,可提高LVEF,改善心功能,减少心绞痛的发作频率。
Objective To discuss clinical curative effect of rosuvastatin calcium on patients with normal blood fat of coronary heart disease （CHD）and left cardiac insufficiency. Methods The patients of normal blood fat of CHD with left cardiac insufficiency （LVEF〈40%）were randomly divided into treatment group and the control group,with 50 cases in each group.Treatment group was given conventional treatment combined with rosuvastatin calcium （10 mg/d, 1 times a night）for six months;Control group was given conventional treatment only.Blood fat,clinical and echocardiographic index changes between two groups was compared respectively. Results After 6 months of treatment,cholesterol,triglycerides, low density lipoprotein cholesterol in treatment group was lower than that before treatment respectively,with statistical difference（P〈0.05）.6 months after treatment,LVEF in treatment group was （52±9）%,LVEF in control group was （42±7）%. 6 months after treatment,LVEF in treatment group was higher than that before treatment,with statistical difference （P〈 0.05）.6 months after treatment, LVEF in treatment group was higher than that of control group,with statistical difference （P〈0.05）. Conclusion Routine treatment combined with rosuvastatin calcium can improve LVEF,cardiac function, and reduce the onset frequency of angina.
出处
《中国当代医药》
2015年第21期76-78,共3页
China Modern Medicine
关键词
瑞舒伐他汀
冠心病
左心功能不全
临床疗效
Rosuvastatin
Coronary heart disease
Left ventricular dysfunction
Clinical effect
