期刊文献+

NSAIDs相关性肠病14例的临床分析

原文传递
导出
摘要 目的:分析因服用非甾体类抗炎药物( NSAIDs)而并发相关性肠病的临床特征。方法:对我院2008年2月~2014年8月间收治的14例NSAIDs相关性肠病患者的临床资料进行回顾性分析。结果:本组14例NSAIDs 相关性肠病患者均存在不同程度的消化道出血,伴或不伴腹痛、腹部不适等症状,便血者多见;经过服药史的调查,14例均存在 NSAIDs 长期服用史,胃镜下均未发现明显出血灶,结肠镜结果示肠道黏膜糜烂,偶可见出血;停用NSAIDs药后,应用抑酸剂及黏膜保护剂可达到治疗效果。结论:服用NSAIDs能显著增加消化道溃疡患者并发出血的风险,NSAIDs相关肠病症状较为隐匿,具有非特异性,临床诊断在考虑用药史、临床症状和主诉的基础上,应结合胃肠镜、胶囊内镜或小肠镜检以帮助提高诊断率。
作者 孙春艳
出处 《中国伤残医学》 2015年第16期116-117,共2页 Chinese Journal of Trauma and Disability Medicine
  • 相关文献

参考文献5

二级参考文献51

  • 1王淑媛,刘琴.非甾体抗炎药相关性上消化道出血64例分析[J].中国现代医学杂志,2006,16(3):444-446. 被引量:10
  • 2Carmona L,Ballina J,Gabriel R,Laffon A.The burden of musculoskeletal diseases in the general population of Spain:results from a national survey.Ann Rheum Dis 2001; 60:1040-1045.
  • 3Wilcox CM,Allison J,Benzuly K,Borum M,Cryer B,Grosser T,Hunt R,Ladabaum U,Lanas A,Paulus H,Regueiro C,Sandler RS,Simon L.Consensus development conference on the use of nonsteroidal anti-inflammatory agents,including cyclooxygenase-2 enzyme inhibitors and aspirin.Clin Gastroenterol Hepatol 2006; 4:1082-1089.
  • 4European Medicines Agency.European Medicines Agency review concludes positive benefit-risk balance for nonselective NSAIDs.London,24 October 2006.Available from:URL:http://www.emea.europa.eu/pdfs/human/press/pr/41313606.pdf.
  • 5October 2006.Available from:URL:http://www.emea.europa.eu/pdfs/human/press/pr/41313606.pdf 4 COX-2 Selective and Non-Selective Non-Steroidal Anti-Inflammatory Drugs NSAIDs.Available from:URL:http://www.fda.gov/cder/drug/infopage/COX2/NSAIDRxTemplate.pdf.
  • 6Arora G,Singh G,Triadafilopoulos G.Proton pump inhibitors for gastroduodenal damage related to nonsteroidal anti-inflammatory drugs or aspirin:twelve important questions for clinical practice.Clin Gastroenterol Hepatol 2009; 7:725-735.
  • 7Sturkenboom MC,Burke TA,Dieleman JP,Tangelder MJ,Lee F,Goldstein JL.Underutilization of preventive strategies in patients receiving NSAIDs.Rheumatology (Oxford) 2003; 42Suppl 3:iii23-iii31.
  • 8Smalley W,Stein CM,Arbogast PG,Eisen G,Ray WA,Griffin M.Underutilization of gastroprotective measures in patients receiving nonsteroidal antiinflammatory drugs.Arthritis Rheum 2002; 46:2195-2200.
  • 9Moore RA,Derry S,Phillips CJ,McQuay HJ.Nonsteroidal anti-inflammatory drugs (NSAIDs),cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm:review of clinical trials and clinical practice.BMC Musculoskelet Disord 2006; 7:79.
  • 10Goldstein JL,Howard KB,Walton SM,McLaughlin TP,Kruzikas DT.Impact of adherence to concomitant gastroprotective therapy on nonsteroidal-related gastroduodenal ulcer complications.Clin Gastroenterol Hepatol 2006; 4:1337-1345.

共引文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部