摘要
目的:评估老年女性乳腺癌患者发病初期的临床特征以及癌胚抗原(carcinoma embryonic antigen,CEA)、糖链抗原12-5(cancer antigen 12-5,CA12-5)和糖链抗原15-3(cancer antigen 15-3,CA15-3)水平对患者预后的预测价值。方法:共纳入52例老年女性乳腺癌患者。记录患者术前确诊时的临床特征,术前检测CEA、CA12-5和CA15-3水平。分析这些因素与患者预后的相关性。结果:肿瘤大小和手术方式对患者生存期的影响差异有统计学意义(P=0.002、0.007)。肿瘤的其他血液学指标(如血清白蛋白、肌酐、乳酸脱氢酶和血红蛋白水平等)及术前血CEA、CA12-5、CA15-3水平均不能作为预测患者生存的独立指标。结论:肿瘤大小和手术方式与老年女性乳腺癌患者的预后密切相关,患者的其他临床特征以及分子标志物与预后的相关性尚待进一步探讨。
Objective：To evaluate the predictive value of baseline clinical features and expression levels of carcinoma embryonic antigen（CEA）,cancer antigen 12-5（CA12-5）and cancer antigen 15-3（CA15-3）for the prognosis of elderly female patients with breast cancer.Methods：Totally fifty-two elderly female patients with breast cancer were recruited in the study.The clinical features at primary diagnosis before operation,as well as the expression levels of CEA,CA12-5,CA15-3 measured before operation,were recorded.The correlation between these factors and patients＇ prognosis was analyzed.Results：The tumor size and the method of operation were significantly correlated with overall survival time（P=0.002 and 0.007）.Other clinical features of tumor（such as serum albumin,creatinine,lactate dehydrogenase and hemoglobin）and preoperative serum levels of CEA,CA12-5,CA15-3 could not be considered as independent predictive factor for patients＇ survival.Conclusions：Tumor size and method of operation are strongly correlated with prognosis of elderly female patients with breast cancer.Further studies could be necessary to confirm the correlation between the patients＇ other clinical features and molecular biomarkers and the prognosis.
出处
《中国临床医学》
2015年第3期398-400,共3页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(编号:81101498)
关键词
乳腺癌
临床特征
分子标志物
预后因子
生存期
Breast cancer
Clinical feature
Biomarker
Prognostic factor
Survival time
