摘要
目的:比较腹腔镜胃癌D2根治术和开腹胃癌D2根治术对患者炎症因子的影响。方法:选取96例胃癌患者随机分为腹腔镜组和开腹组,腹腔镜组采用腹腔镜胃癌D2根治术治疗,开腹组采用开腹D2根治术治疗,比较两组术前及术后CRP、IL-6、TNF-α及IL-10水平。结果:腹腔镜组术中出血量明显少于开腹组,手术时间、术后排气时间及术后下床活动时间少于开腹组,差异比较有统计学意义(P<0.05);两组术后1 d CRP、IL-6、TNF-α及IL-10水平较术前明显升高,差异比较有统计学意义(P<0.05);腹腔镜组术后CRP、IL-6、TNF-α水平明显低于开腹组,IL-10水平高于开腹组,差异比较有统计学意义(P<0.05)。结论:腹腔镜胃癌D2根治术较开腹胃癌D2根治术炎症反应轻,创伤小,可在临床上推广。
Objective： To compare the effect of laparoscopic D2 gastrectomy and open D2 gastrectomy on inflammatory reaction in patients with gastric cancer. Methods： The 96 patients with gastric cancer were randomly divided into laparoscopic group and open group. Patients in laparoscopic group were given treatment of laparoscopic D2 gastrectomy. and those in open group were accepted treatment of open D2 gastrectomy. The levels of CRP, IL-6, TNF-α and IL-10 were compared before operation and after operation. Results： The blood loss of laparoscopic group significantly lower than open group, operation time, postoperative exhaust time and postoperative ambulation time less than open group, the difference was statistically significant （P〈0.05）; the levels of CRP, IL-6, TNF-α and IL-10 at 1 day after operation were significantly higher than before operation, the difference was statistically significant （P〈0.05）; the levels of CRP, IL-6 and TNF-α of laparoscopic group after operation lower than open group, the levels of TNF-α higher than open group, the difference was statistically significant （P〈0.05）.Conclusion： Compared with open D2 gastrectomy, laparoscopic D2 gastrectomy has a significant advantage in small trauma, slight inflammatory reaction. It can be applied in clinical practice.
出处
《临床与病理杂志》
CAS
2015年第7期1298-1303,共6页
Journal of Clinical and Pathological Research
关键词
腹腔镜
胃癌
根治术
炎症因子
laparoscopy
gastric cancer
gastrectomy
inflammation levels
