摘要
目的探讨应用高压氧、针灸联合小剂量美多巴治疗对帕金森综合征（Parkinson disease，PD）患者生活质量的改善作用。方法选择PD患者140例，经患者及家属知情同意，将患者按照治疗方法分为A组（针灸十美多巴组，20例）、B组（高压氧十美多巴组，20例）、c组（高压氧＋针灸＋小剂量美多巴组，60例）、D组（小剂量美多巴组，40例），用生活质量评定量表（EQ-5D）、统一PD评定量表（UPDRS）、Hoehn—Yahr（H—Y）分级、PD睡眠量表（PDSS）、汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA），评估PD患者运动、非运动症状改善及生活质量改善情况。结果（1）4组患者经短期治疗（治疗1个月）后UPDRSI、UPDRS11、UPDRSmA组t值分别为7．71，6．14，6．50；B组t值分别为6．87、6．09、6．66；C组t值分别为6．69、6．66、9．68；D组t值分别为7．79、6．07、6．41。HAMA、HAMD、PDSS、EQ-5D评分较治疗前明显改善，差异有统计学意义（P〈0．05）。提示4种治疗方案短期内皆可改善患者运动和非运动症状，提高PD患者生活质量；C组在UPDRSⅢ、HAMA、HAMD、PDSS方面改善更显著，差异有统计学意义（P〈0．05）。（2）长期治疗（6个月）后C组患者UPDRSm、HAMA、HAMD、PDSS评分与D组相比差异有统计学意义（P〈0．05）。（3）长期治疗（6个月）后，C组患者的生活质量呈上升趋势，与其他组比较差异有统计学意义（P〈0．05）。结论高压氧、针灸联合小剂量美多巴可提高PD患者生活质量。
Objective To investigate the effects of hyperbaric oxygen （HBO） combined with acupuncture and low-dose L-dopa on the improvement of motor and non-motor symptoms and life quality of the patients with Parkinson＇s disease. Methods One hundred and forty PD patients were chosen for our study. With the knowledge and consent of the patients and their dependents, the patients were divided into 4 groups, by different treatment methods ： group A （ the acupuncture plus small-dose L-dopa group, n = 20 cases）, group B （ the HBO plus small-dose L-dopa group, n = 20 cases） , group C （ the HBO plus acupuncture and plus small-dose L-dopa group, n = 60 cases ） , and group D （ the small-dose L-dopa group, n = 40 cases ）. Improvement of motor and non-motor symptoms and their life quality of the patients were assessed hy using the EQ-SD, Uniform Parkinson＇s Disease Rating Scale （UPDRS） , Hoehn-Yahr （H-Y） Rating Scale, Parkinson＇s Disease Sleep Scale （PDSS）, Hamilton Anxiety Rating Scale （HAMA） and Hamilton Depression Rating Scale （HAMD）. Results （ 1 ） After one month of treatment, the scores of UPDRS Ⅰ, UPDRS Ⅱ and UPDRS Ⅲ for group A were respectively 7.71, 6. 14 and 6.50, the scores for group B were respectively 6.87, 6.09 and 6.66, the scores for group C were respectively 6.69, 6. 66 and 9.68, and the scores for group D were respectively 7.79, 6.07 and 6.41. The scores of HAMA, HAMD, PDSS and EQ-SD were significantly improved as compared with those before treatment（ P 〈 0.05 ）, indicating that the 4 treatment profiles within a relatively short time could all improve the motor and non-motor symptoms and life quality of the PD patients The scores of UPDRS m, HAMA, HAMD and PDSS for group C were more significantly improved （P 〈 0.05 ）. （2） After 6 months of prolonged treatment, statistical significance could be noted in the scores of UPDRS Ⅲ, HAMA, HAMD and PDSS in the patients of group C （ P 〈 0.05 ）. （ 3 ） Following 6 months of prolonged treatment, the life quality of the patients in group C tended to improve, and statistical significance could also be noted, when comparisons were made with that of the other groups （P 〈 0.05）. Conclusions HBO combined with acupuncture and small-dose L-dopa could reduce the dosage of L-dopa, decrease adverse reactions and improve the life quality of patients with Parkinson＇s disease.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2015年第3期187-191,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
基金
山东省自然科学基金（ZR2013HQ003）
关键词
高压氧
针灸
帕金森综合征
生活质量
运动症状
非运动症状
Hyperbaric oxygen
Acupuncture
Parkinson＇s disease
Life quality
Motor symptom
Non-motor symptom
