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Th17细胞及相关细胞因子在乙型病毒性肝炎中的作用机制 被引量：2

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摘要 Th17细胞是在对实验性自身免疫性脑脊髓炎（EAE）和胶原诱导的关节炎（CIA）这两种动物模型的研究中被发掘的。研究者在实验中发现,通过清除Th1样细胞因子IL-2或IFN-γ并不能有效预防或缓解病情,而IL-23在这些疾病的进程中反而显示出了极为重要的作用。之后研究表明,IL-23可以促进CD4＋T细胞产生炎性细胞因子IL-17,由此,这种不同于Th1、Th2的IL-17＋细胞作为一种新的Th细胞亚群才被发掘疆命名为Th17。
作者 王兰 杨帆 张丽 杨瑞宁
机构地区 解放军第八一医院
出处 《肝脏》 2015年第5期410-412,共3页 Chinese Hepatology
关键词 TH17细胞 相关细胞因子 乙型病毒性肝炎 实验性自身免疫性脑脊髓炎 IL-23 CD4+T细胞 炎性细胞因子 TH细胞亚群
分类号 R512.62 [医药卫生—内科学]
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参考文献22

  • 1Park H,Li Z, Yang XO,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol, 2005,6 : 1133-1142.
  • 2Wu W, Li J, Chen F, et al. Circulating Thl7 cells frequency is associated with the disease progression in HBV infected patients. J Gastroenterol Hepatol, 2010,25 : 750-757.
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二级参考文献13

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  • 7Belladonna ML,Renauld JC, Bianchi R, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol,2002,168:5448-5454.
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肝脏
2015年 第5期

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