摘要
目的探讨非小细胞肺癌患者组织中IL-27和LTB4检测情况及临床意义。方法采用免疫组化法检测50例非小细胞肺癌组织中的IL-27和LTB4的表达情况。结果 50例非小细胞肺癌组织中IL-27和LTB4总阳性表达率分别为42.00%和66.00%,正常组织中为86.67%和13.33%,差异均有统计学意义(均P<0.05)。吸烟指数≥400组IL-27表达水平低于吸烟指数<400组,而LTB4表达水平高于吸烟指数<400组(均P<0.05)。IL-27和LTB4的表达均与肺癌分化程度相关(均P<0.05),并且IL-27和LTB4之间有负相关性(r=-0.713)。结论在非小细胞肺癌的发生、发展过程中,IL-27和LTB4与之有着密切关联,通过对二者联合检测对其临床诊治有重要意义。
[Objective]To investigate the detection and clinical significance of IL-27 and LTB4 in tissue of patients with non-small cell lung cancer. [Methods]The expression levels of IL-27 and LTB4 in tissue of 50 cases of non-small cell lung cancer were detected by Immunohistochemical method.[Results]The positive expression rates of IL-27 and LTB4 in tissue of 50 cases of nonsmall cell lung cancer were 42.00% and 66.00%,in normal tissue were 86.67% and 13.33%,the differences were statistically significant（all P〈0.05）. The expression level of IL-27 in patients with smoking index ≥400 was lower than that in patients with smoking index〈400,and the expression level of LTB4 was higher than that in patients with smoking index 〈400（all P〈0.05）. The expressions of IL-27 and LTB4 were related with the degree of tumor differentiation（P 〈0.05）,and there was a negative correlation between IL-27 and LTB4（r =-0.713）. [Conclusion]The IL-27 and LTB4 are related to the pathogenesis and development of non-small cell lung cancer. There were important significance for clinic diagnosis and treatment of non-small cell lung cancer by joint detection of IL-27 and LTB4.
出处
《职业与健康》
CAS
2015年第14期1903-1905,共3页
Occupation and Health
基金
黑龙江省卫生厅科研课题(项目编号:2013247)
