摘要
恶性黑色素瘤是一种由于黑素细胞异常增殖引起的皮肤肿瘤,其发病率高、恶性程度高,严重威胁人类健康。恶性黑色素瘤发病早期,可手术切除病灶,但对于中晚期患者的治疗,目前上市的靶向药物均对其不敏感,且易产生耐药性。中药成分复杂,耐药性低,已证实其中含有结构新颖、药理活性显著的先导抗肿瘤成分,这些成分有的能同时或协同作用于多个靶点,使在其中筛选出符合临床要求的多靶点治疗药物成为可能。本文对已发现的抗恶性黑色素瘤中药活性成分及其作用机制进行综述,为开发理想的抗肿瘤药物提供依据。
Malignant melanoma is a kind of skin tumor which is caused by excessive proliferation of the abnormal melanocytes with an increasing incidence and a high degree of malignancy, it is a serious threat to human health. Treatment for the early stage of malignant melanoma is surgical removal. Nowadays, the targeted drug in market is not sensitive to it and it is easy to develop resistance to other antitumor drugs for the patients who are in the middle-advanced period. The components of Chinese herbs are complicated and the drug resistance of Chinese herbs is low, which has been proved novel structure and leading pharmacological activity of antitumor components exist, these components not only have effect on several targets, but also have synergistic effects on multiple targets. These antitumor components make the screening of multiple targeted drugs meeting the clinical demand possible. This paper reviews the active components of Chinese herbs and molecular mechanism in order to provide the basis for the development of ideal antitumor drugs.
出处
《中国医药导报》
CAS
2015年第23期29-33,共5页
China Medical Herald
基金
黑龙江省教育厅科学技术研究项目(12521501)
黑龙江省自然科学基金面上项目(D201275)
关键词
中药
靶向治疗
恶性黑色素瘤
分子机制
Chinese medicine
Targeted treatment
Malignant melanoma
Molecular mechanism
