摘要
目的:探讨药物性肝损害(DILI)的临床特点及其发生规律,为临床合理用药提供参考。方法:对我院2005-2014年发生的104例药物性肝损害患者的性别、年龄、发病时间、药品品种、临床表现等临床资料进行回顾性分析。结果:DILI住院病例逐年增多,其中男性47例,女性57例,平均年龄(48.71±13.90)岁;开始用药后至开始出现临床症状时间绝大多数在12周以内;临床症状包括纳差、乏力、身目黄染、上腹不适等,均无特异性;10.57%患者为无症状,临床分型以肝细胞损伤型最多(80.77%),胆汁淤积型次之(12.50%),混合型最少(6.73%)。最常见的引起肝损害药物依次为中药、抗微生物药、抗肿瘤药和神经系统药。结论:DILI患者中女性稍多于男性,好发于40岁以上;临床表现多样且不明显,引起肝损害的药品较多,临床医师在工作中应提高对该病的重视,根据DILI的特征,早期识别,及时停药和合理处置是其诊治的关键。
OBJECTIVE：To explore the clinical features and regularity of drug-induced liver injury（DILI）,and to provide reference for clinical rational drug use. METHODS：104 DILI cases in our hospital from 2005 to 2014 were selected and analyzed retrospectively in respects of patient＇s gender,age,allergic history,medication history,drug type and clinical manifestations. RESULTS：DILI hospitalized cases increased year by year. There were 47 males and 57 females,and average age was（8.71±13.90）.The clinical symptoms appeared within 12 weeks after using the drug. The symptoms were no specific,including weak,anorexia,jaundice,yellow urine,etc. and 10.57% of patients were asymptomatic. Most of the DILI cases were hepatocyte type（80.77%）,followed by cholestasis type（12.50%）and hybrid type（6.73%）. The most common cause of drug-induced liver injury were TCM,antimicrobial drugs and the nervous system drugs. CONCLUSIONS：The incidence of DILI in females is slightly higher than males.DILI often occurs after 40 years old. The clinical symptoms have no specificity and are similar to viral hepatitis. The hepatic lesions can be caused by most of drugs. DILI by TCM should concerned. Clinical physicians should pay more attention to DILI.
出处
《中国药房》
CAS
北大核心
2015年第23期3226-3228,共3页
China Pharmacy
基金
齐齐哈尔市科学技术计划项目(No.SFZD-2013067)
