摘要
目的探讨快速康复外科(FTS)对胰腺癌手术后患者营养状况及免疫功能的影响。方法选取胰腺癌手术患者120例,随机分为快速康复外科组(观察组)印例和传统治疗组(对照组)60例,对照组采用传统方法康复,观察组采用快速康复外科理念,分别检测各个时段血红蛋白(Hb)、血清白蛋白(Alb)、前白蛋白(PAB)、转铁白蛋白(TRF)等营养指标及IgA、IgG、IgM、CD_3^+、CD_4^+、CD_4^+/CD_8^+等免疫指标浓度,并进行对比分析。结果 2组患者术前Hb、Alb、PAB、TRF浓度无明显差异(P>0.05);术后第1天均显著下降(P<0.05),术后第5天又略有上升,且观察组术后第5天血清PAB、TRF浓度明显高于对照组(P<0.05)。2组患者IgA、IgG、IgM浓度于术后第1天较术前均明显降低(P<0.05),但对照组降低更明显,术后第5天观察组恢复至术前浓度水平,但对照组仍明显低于术前(P<0.05)。2组患者CD_3^+、CD_4^+、CD_4^+/CD_8^+浓度于术后第1天明显降低(P<0.05),但对照组降低更明显,术后第5天观察组恢复至术前浓度水平,但对照组仍明显低于术前浓度水平(P<0.05)。结论快速康复外科理念能明显改善胰腺癌术后患者的营养状况,保护免疫功能,加速患者术后康复,值得大力推广。
Objective To investigate the effect of rapid rehabilitation surgery （FTS） on nutritional status and im- mune function of patients with pancreatic cancer after surgical operation. Methods Selected 120 cases of patients with pan- creatic cancer surgery, they were randomly divided into fast track surgery group （observation group, 60 cases） and conven- tional treatment group （ control group, 60 cases） , the control group using the traditional methods of health care, the observa- tion group using fast track surgery nursing, each period＇ s hemoglobin （Hb） , serum albumin （Alb） , prealbumin （ PAB ） , turn iron albumin （TRF） and other nutritional indicators and IgA, IgG, IgM, CDa＋ ,CD;, CD4＋/CDs＋ immune index concen- tration were tested, and analysis were performed. Results 2 groups of patients＇ preoperative Hb, Alb, PAB, TRF concentra- tion had no significant differences （ P 〉 0.05 ） ; the first day after operation, these indices were significantly decreased （ P 〈 0.05 ） , the fifth day after operation, the observation group＇ s serum PAB, TRF concentration was significantly higher than that of control group （ P 〈0.05）. IgA, IgG and IgM concentrations at postoperative day 1 were significantly decreased than the preoperative in both of the two groups （ P 〈 0.05 ） , but the control group decreased more significantly, after operation＇ s 5th day, observation group recovered to preoperative levels, but control group remained significantly lower than preoperative level （ P 〈 0.05 ）. CD3＋ , CD4＋ , CD4/CDs concentration on postoperative day 1 was significantly decreased in both of the two groups （ P 〈 0.05 ） , but the control group decreased more significantly, after operation＇s 5th day, observation group recov- ered to preoperative levels, but control group remained significantly lower than preoperative levels （ P 〈 0.05 ）. Conclusion Rapid rehabilitation surgery can significantly improve the nutritional status of pancreatic cancer patients after surgery, pro- tect the immune function, accelerate postoperative recovery, it is worthy of application.
出处
《疑难病杂志》
CAS
2015年第8期838-841,共4页
Chinese Journal of Difficult and Complicated Cases
基金
2011年河北省科技指导性计划(No.11276103D-61)
河北省张家口市科技指导计划(No.1101119D
关键词
快速康复外科
胰腺癌
营养状况
免疫功能
Rapid rehabilitation surgery
Pancreatic cancer
Nutritional status
Immune function
