摘要
目的探讨注意力缺陷多动障碍(ADHD)的临床相关因素,评价抑肝散治疗小儿多动症的临床效果。方法入选120例ADHD患儿作为研究对象,健康儿童120例作为对照组,通过问卷调查形式评价家庭环境、儿童生活习惯、儿童环境毒物接触情况对ADHD的影响。另选取患儿中证属脾虚肝亢者75例,其中试验组38例,对照组37例,对照组给予单纯行为治疗,每周3次;试验组在对照组治疗基础上,口服加味抑肝散150 m L,一日2次,疗程为8周,分别于入组前,治疗后4,8周行中医证候积分评定和疗效判断。结果父母学历低于初中、采取责罚教育方式、家庭月收入低于每月3000元、单亲或隔代抚养家庭、人工喂养、父母为独生子女均为发生ADHD的危险因素。作息不规律、缺乏爱好、睡眠紊乱、易食零食,接触增塑剂(DEHP)次数越多及玩手机次数越频繁更易患ADHD。试验组控显率为52.63%,总有效率为86.84%;对照组控显率为24.32%,总有效率为43.24%,试验组疗效优于对照组(P<0.01)。治疗8周后,2组中医证候积分均显著降低(P<0.01),试验组治疗后中医证候积分低于对照组,其改善程度更显著。结论 ADHD发生与家庭环境、儿童生活习惯及接触环境毒物有一定关系;抑肝散治疗脾虚肝亢型ADHD疗效确切。
Objective To explore the deficit hyperactivity disorder （ADHD） main influence factors of attention and evaluate the clinical effect of Yi- gan -san modified. Methods Questionnaire survey consisting of home environment, living habits and exposure to environmental toxicant was used to investigate and evaluate children in the two groups, one of them was the study group with 120 cases of ADHD children, and the other was the control group with 120 cases of healthy children. A total of 75 cases with the pi -xu -gan -kang type were found among the ADHD children, and they were randomly divided into 2 groups： the experimental group （ n = 38 ）, using drug therapy of Yi - gan - san modified （ 150 mL, twice a day ）and behavioral therapy （3 times a week） ; the control group, using behavioral therapy alone. The treatment lasted for all 8 weeks. The data of the line integral of traditional Chinese medicine symptom assessment was used to evaluate the curative effect before treatment and 4, 8 weeks after treatment. family environment such as low Results The survey found that the education level of parents, parenting methods, family income less than three thousand yuan each month, parenting and feeding patterns, whether both parents were the only child in the family were significantly associated with the occurrence of ADHD. We also found the exposure to DEHP, children＇s rest hobbies, sleep habits, eclipse snack times and playing phone were significantly related with the occurrence of ADHD. The CR of the treatment group was 52.63% and the total effective rate was 86. 84%, and there was 24.32% and 43.24% in the control group respectively. The TCM syndrome score between the two groups had significant statistical significance （ P 〈 0.01 ）, and the curative effect of the treatment group was better than that in the control group. The TCM syndrome score were significantly lowered after 8 weeks of treatment in the two groups （P 〈0. 01 ）. Conclusion The family environment, lifestyle and children＇ exposure to environmental toxicants were susceptible to the occurrence of ADHD. Using Yi - gan - san modified intervention for the treatment of ADHD is effective.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2015年第15期1480-1483,共4页
The Chinese Journal of Clinical Pharmacology
基金
唐山市级发展与指导计划基金资助项目(10130233a)
关键词
抑肝散
小儿多动症
家庭环境
生活习惯
环境毒物
Yi - gan - san
ADHD
family environment
habit and custom
environmental toxicology
