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当归芍药散联合丹参注射液治疗早发型重度子痫前期临床研究 被引量:15

Clinical research of Danggui- shaoyao powder combined with Danshen injection on early onset severe preeclampsia
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摘要 目的观察当归芍药散联合丹参注射液治疗早发型重度子痫前期(EOSP)的临床疗效。方法将100例EOSP患者随机分为2组,对照组50例予硫酸镁及盐酸拉贝洛尔治疗,治疗组50例在对照组治疗基础上加当归芍药散联合丹参注射液治疗。比较2组治疗前后凝血指标D-二聚体(DD)水平、血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆纤维蛋白原(Fbg),肾功能指标24 h尿蛋白定量、尿酸(UA)、肌酐(Cr)、尿素氮(BUN)变化,评估母婴预后情况。结果治疗组治疗后DD、Fbg、24 h尿蛋白定量、UA、Cr及BUN均较本组治疗前及对照组治疗后明显降低(P<0.05);孕妇肾损害、心功能不全、胎盘早剥、HELLP综合征发生率明显低于对照组(P<0.05)。与对照组比较,治疗组围生儿胎龄延长时间延长,新生儿体质量明显增加,胎儿窘迫发生率、新生儿窒息发生率及死亡率明显降低,比较差异均有统计学意义(P<0.05)。结论当归芍药散联合丹参注射液治疗可改善EOSP患者高凝状态,增强纤溶活性,改善肾脏功能,有效降低孕妇并发症发生,改善围生儿预后。 Objective To observe the curative effects of Danggui - shaoyao powder combined with Danshen injection on early onset severe pre - eclampsia (EOSP). Methods 100 EOSP patients were randomly divided into two groups. 50 patients in control group were treated by magnesium sulfate and labetalol hydrochloride. 50 patients in treatment group were treated by Danggui - shaoyao powder combined with Danshen injection on the basis of control group treatment. The changes of coagulation indexes of D - dimer level ( DD), prothrombin time (PT), activated partial thromboplastin time (APTT) ,thrombin time (TT) and plasma fibrinogen (Fbg) ,the changes of renal function indexes of 24 h uriu protein, uric acid (UA), creatiniue (Cr) and blood urea nitrogen (BUN) before and after treatment were compared in two groups, and the prognosis of mother and child were analyzed. Results The levels of DD, Fbg,24 h urin protein, UA, Cr and BUN after treatment in treatment group were obviously decreased (P 〈 0.05). The occurrence rate of kidney damage, cardiac insufficiency, placental abruption and HELLP syndrome in treatment were obviously lower than those in control group (P 〈 0.05). The gestational age of perinatal infant was extended in treatment group, and the newborn' s weight was obviously increased, there were significant differences between two groups ( P 〈 0.05 ). The occurrence rate of fetal distress, neonatal asphyxia and death in treatment group were obviously decreased as compared with those in control group ( P 〈 0.05 ). Conclusion Combined therapy of Danggui - shaoyao powder and Danshen injection can improve the hypercoagulable state in EOSP patients, enhance the fibrinolysis, improve the kidney function, could effectively reduce maternal complications, improve the prognosis of perineonate.
出处 《河北中医》 2015年第7期1039-1043,共5页 Hebei Journal of Traditional Chinese Medicine
关键词 当归芍药汤 丹参注射液 妊娠结局 先兆子痫 预后 Danggui - shaoyao powder Danshen injection Pregnancy outcome Preeclampsia Prognosis
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