摘要
[目的]总结骨折内固定术后感染抗生素治疗的新进展。[方法]查阅近年关于骨折内固定术后感染抗生素治疗的相关文献,进行综述分析。[结果]系统抗生素的选择应参照细菌培养结果,抗生素用药时间一般不超过4~6周,口服与静脉疗效相似,但口服用药并发症发生率更低且花费更少;达托霉素在治疗骨感染中的疗效已引起关注;怀疑生物膜细菌感染时,应联合应用利福平或氟喹诺酮类抗生素;局部应用抗生素载体以硫酸钙为典型代表,其可完全降解,生物相溶性好,有良好的骨传导及药物缓释功能。[结论]合理的系统联合局部应用抗生素能有效降低内固定术后感染的复发率,提高患者生活质量。
[Objective] To summarize the latest progress of antibiotic treatment for fracture implant - associated infections. [ Method] Recent literatures regarding antibiotic treatment for fracture implant- associated infections were reviewed and ana- lyzed. [ Result ] Selection of systematic antibiotics should comply with the bacteria culture outcomes. Antibiotic treatment dura- tion should be less than four to six weeks. Current studies suggest that oral antibiotics can achieve similar efficacy as parenteral approach does. However, the risk of complications and medical cost following oral antibiotics is lower than parenteral medication. The effect of daptomycin in treatment of hone infection has caused attention. Combination of rifampicin and fluoroquinolones should be applied when biofilm infection is suspected. As a typical representative, calcium sulfate has several advantages as a carrier including complete degradability, ~ biocompatibility, esteoconduction and effect of drug sustained release. [ Conclusion] Reasonable combination medicate and local antibiotic use can effectively reduce the recurrence risk of fracture implant - associated infections and can also improve the quality of life for these patients.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2015年第16期1489-1492,共4页
Orthopedic Journal of China
基金
国家自然科学基金(编号:31440043)
关键词
内固定相关感染
骨髓炎
硫酸钙
抗生素治疗
fracture implant - related infection, osteomyelitis, calcium sulphate, antibiotic treatment
