摘要
目的探索中性粒细胞CD64指数在社区获得性肺炎(CAP)临床应用的价值。方法回顾性分析我院64例能找到病学原依据的CAP患者,其中细菌性肺炎患者30例,肺炎支原体肺炎34例,并用30例健康者为对照组,测定CD64指数,降钙素原(PCT),超敏CRP,白细胞计数。结果细菌性肺炎组在CD64指数、PCT、超敏CRP及白细胞计数方面均高于肺炎支原体肺炎组及对照组,差异具有统计学意义(P<0.05)。并且CD64指数与PCT、超敏CRP、白细胞计数具有正相关性,差异具有统计学意义(P<0.05)。同时对CAP进行治疗前与治疗后比较,发现治疗后CD64指数明显下降,差异具有统计学意义(P<0.05)。依据肺炎严重度指数(PSI)将CAP分为低危组与高危组,发现低危组CD64指数低于高危组,差异具有统计学意义(P<0.05)。结论 CD64指数可以用于CAP细菌感染的判断,并可用于指导抗菌药物的治疗,在病情评估方面亦具有临床实用价值,值得进一步研究。
Objective To investigate the clinical application value of neutrophil CD64 index in community -acquired pneumonia （CAP）. Methods 64 patients who were diagnosed as CAP were collected, including 30 cases of bacteria pneumonia and 34 cases of mycoplasma pneumoniae pneumonia. At the same time, 30 healthy people were taken as the control group. Their CD64 index, PCT, hsCRP and WBC count were tested. Results Their CD64 in-dex, PCT, hsCRP and WBC count were obviously higher in the bacteria pneumonia group than in the mycoplasma pneumoniae pneumonia group and in the control group （P〈0. 05）. Meanwhile, CD64 index was positively correlated with PCT, hsCRP and WBC count （P〈0. 05）. CD64 index decreased obviously after the treatment in the bacteria pneumonia group, and it was lower in the low risk group than in the high risk group （P〈0. 05）. Conclusion CD64 index can be used to judge bacteria infection, guide the treatment of antimicrobial drugs, and assess the severity.
出处
《临床肺科杂志》
2015年第9期1664-1666,共3页
Journal of Clinical Pulmonary Medicine
