摘要
目的探讨动脉粥样硬化血栓性脑梗死及腔隙性脑梗死与幽门螺杆菌(Hp)感染之间的相关性,以期能为脑梗死的诊治提供参考依据。方法选取2009年3月-2014年3月初发性急性脑梗死患者121例,根据患病病因不同分组,动脉粥样硬化血栓性脑梗死患者87例为A组,腔隙性脑梗死34例为B组,选取同期门诊无脑梗死老年患者60例为对照C组,对比其临床指标,数据采用SPSS17.0软件进行统计分析。结果 A、B、C组Hp感染阳性率分别为87.36%、41.18%、35.00%,比较差异有统计学意义(P<0.05),两两比较A组感染阳性率高于B组与C组(P<0.05),各组TNF-α、CRP、IL-18水平比较差异有统计学意义(P<0.05),比较A组TNF-α、CRP、IL-18水平明显高于B组与C组(P<0.05)。结论动脉粥样硬化血栓性脑梗死患者Hp感染阳性率及相关炎症因子水平明显高于腔隙性脑梗死患者,腔隙性脑梗死患者Hp感染阳性率与无脑梗死老年患者差异无统计学意义,提示Hp感染与动脉粥样硬化血栓性脑梗死关系密切。
OBJECTIVE To explore the correlation of atherosclerotic thrombotic cerebral infarction and lacunar cere‐bral infarction with Helicobacter pylori （Hp） infection ,so as to provide clinical reference basis for the diagnosis and treatment of cerebral infarction .METHODS Totally 121 patients with early onset of acute cerebral infarction during Mar .2009 to Mar .2014 were selected and grouped according to different disease causes ,i .e .,group A of 87 patients with atherosclerotic thrombotic cerebral infarction ,group B of 34 patients with lacunar cerebral infarc‐tion ,meanwhile 60 elderly outpatients without cerebral infarction during the same period were selected as group C .The clinical indexes were compared and the software SPSS17 .0 was used for statistical analysis .RESULTS The positive rate of Hp infection for groups A ,B ,C was 87 .36% ,41 .18% and 35 .00% respectively ,with statistical‐ly difference （P〈 0 .05） .The infection positive rate for group A was higher than group B and group C （P〈0 .05） .The differences in the level of TNF alpha ,CRP ,IL‐18 were significant （P〈0 .05） ,and the TNF alpha , CRP ,IL‐18 level in group A was significentltly higher than in group B and group C （P〈0 .05） .CONCLUSION The Hp infection positive rate and the related inflammatory factor level in patients with atherosclerotic thrombotic cerebral infarction were significentltly higher than in patients with lacunar cerebral infarction ,and there was no obvious difference in the Hp infection positive rate between patients with lacunar cerebral infarction and patients without cerebral infarction ,indicating that Hp infection was closely associated with atherosclerotic thrombotic cer‐ebral infarction .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第16期3669-3671,共3页
Chinese Journal of Nosocomiology
基金
河南省教育厅科学技术研究基金资助项目(12B140011)
关键词
老年患者
动脉粥样硬化性脑梗死
腔隙性脑梗死
幽门螺杆菌
Elderly patients
Atherosclerotic cerebral infarction
Lacunar cerebral infarction
Helicobacter pylori
